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Breast cancer prognostic significance of some modified urinary nucleosides

Breast cancer prognostic significance of some modified urinary nucleosides,10.1016/S0304-3835(96)04393-5,Cancer Letters,Annie J. Sasco,Françoise Rey,C

Breast cancer prognostic significance of some modified urinary nucleosides   (Citations: 14)
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The prognostic significance of six urinary modified nucleosides, 5-methylcytidine (5-MeCyd), 4-acetylcytidine (4-AcCyd), 1-methylinosine (1-MeIno), 1-methyladenosine (1-MeAdo), 7-methylguanosine (7-MeGua) and pseudouridine (Ψ-Urd) was evaluated in 68 breast cancer patients of the specialized cancer hospital of Lyon (France). Excretions of 1-MeIno and 1-MeAdo were significantly higher in patients hospitalized in the medical rather than surgical ward, reflecting more advanced disease, and also among patients who died within 5 years of follow-up as compared to those still alive. These results suggest an unfavourable prognostic significance of high urinary excretion of 1-MeIno and 1-MeAdo in breast cancer patients.
Journal: Cancer Letters - CANCER LETT , vol. 108, no. 2, pp. 157-162, 1996
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