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Integrin  3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk

Integrin  3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk,10.1136/jmg.2006.047498,Journal of Medical Genetics,A. Jakubowska,J.

Integrin  3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk   (Citations: 9)
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Journal: Journal of Medical Genetics - J MED GENET , vol. 44, no. 6, pp. 408-411, 2007
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    • ...A recent study conducted of Polish BRCA1 mutation carriers including 319 breast cancer cases, 146 ovarian cancer cases and 290 unaffected controls reported a significantly increased risk of ovarian cancer among carriers of the ITGB3 33Pro allele (ORadj 2.51, 95% CI 1.30‐4.84, P = 0.006) [44]...
    • ...typed by PCR-based restriction fragment length polymorphism (RFLP) analysis as previously described [44]...
    • ...Since the original study (IHCC), where an association was reported [44], consists predominantly of class 2 mutations (*94% of all BRCA1 mutations in IHCC), we repeated the analysis by excluding the IHCC study and found no evidence of an association (HR 1.01, 95% CI 0.78‐1.32, p-trend = 0.92)...
    • ...Results from a smaller study had previously suggested that this polymorphism is associated with the risk of ovarian cancer in BRCA1 mutation carriers [44]...

    Anna Jakubowskaet al. The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2 -a...

    • ...This study has used a two-stage case–control candidate gene approach and identified a panel of protective and susceptibility SNPs that individually confer only small effects (OR ranging from 0.3 to 2.6). This is very much in keeping with the experience from case–control association studies to date. ...

    R P Younget al. A gene-based risk score for lung cancer susceptibility in smokers and ...

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