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Preserved Immune Functions and Controlled Leukocyte Oxidative Stress in Naturally Long-lived Mice: Possible Role of Nuclear Factor Kappa B

Preserved Immune Functions and Controlled Leukocyte Oxidative Stress in Naturally Long-lived Mice: Possible Role of Nuclear Factor Kappa B,10.1093/ger

Preserved Immune Functions and Controlled Leukocyte Oxidative Stress in Naturally Long-lived Mice: Possible Role of Nuclear Factor Kappa B   (Citations: 5)
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    • ... suspension (a relatively noninvasive sample of easy access in mice), experimental research previously conducted by our group has shown that peritoneal cells of aged mice display impairments in several of their functions and an increase in a variety of oxidative-inflammatory stress parameters (which have been proposed as markers of biological age, premature ageing and consequently predictors of longevity) (De la Fuente and Miquel 2009; Arranz ...

    Isabel Baezaet al. Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritone...

    • ...Reactive oxygen species (ROS), such as superoxide anion, hydrogen peroxide and the highly reactive hydroxyl radical, play an important role in normal biological functions, and contribute to the pathogenesis of a variety of diseases (Ames et al. 1993; Halliwell and Gutteridge 1990)...

    Carmen Vidaet al. The aged-related increase in xanthine oxidase expression and activity ...

    • ...Thus, an oxidant-antioxidant balance is needed to maintain a correct immune function and the unbalance with more oxidant than antioxidant defences, i.e., the oxidative stress, as occurs in ageing, is the basis of immunosenescence [2, 5]. In addition, it is also known that the immune cell function is a health biomarker and longevity predictor [2, 6, 7]. Recently, it has been suggested that the immune cells can...

    Mónica De la Fuenteet al. Improvement of leucocyte functions in mature and old mice after 15 and...

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