Keywords (7)

Academic

Publications

Targeting the neural cell adhesion molecule in cancer

Targeting the neural cell adhesion molecule in cancer,10.1016/j.canlet.2007.09.004,Cancer Letters,Markus Jensen,Frank Berthold

Edit

Targeting the neural cell adhesion molecule in cancer (Citations: 15)


	BibTex \| RIS \| RefWorks Download

NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies. From the spectrum of existing anti-NCAM compounds, radioimmunoconjugates and immunotoxins represent the clinically most advanced and successful strategies. Here we provide an overview of the evolving field of anti-NCAM immunotherapy for cancer and discuss its indications and limitations.

Journal: Cancer Letters - CANCER LETT , vol. 258, no. 1, pp. 9-21, 2007

DOI: 10.1016/j.canlet.2007.09.004

Cumulative Annual

View Publication

( www.sciencedirect.com )

( linkinghub.elsevier.com )

Citation Context (2)

- ...Although NCAM-1 is known to be overexpressed in many brain cancers, small cell lung cancer, and multiple myeloma, is has not generally been discussed as a marker for breast cancer [51]...
Jennifer J Hill, et al. Glycoproteomic analysis of two mouse mammary cell lines during transfo...
- ...Together with the use of NCAM as a tumor antigen suitable for antibody-based targeting strategies [67], the identification of NCAM-dependent signaling in tumor cells should provide the rationale for novel therapeutic strategies against specific cancer types...
Silvia Zecchini, et al. Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms

Sort by:

Citations (15)

Polymyositis, dermatomyositis and malignancy: A further intriguing link (Citations: 14)

, , , , , , , , , , , http://academic.research.microsoft.com/io.ashx?type=5&id=36143525&selfId1=0&selfId2=0&maxNumber=12&query=

Journal: Autoimmunity Reviews - AUTOIMMUN REV , vol. 9, no. 6, pp. 449-453, 2010

Target Visualization by MRI Using the Avidin/Biotin Amplification Route: Synthesis and Testing of a Biotin-Gd-DOTA Monoamide Trimer

, , , , , ,

Journal: Chemistry-a European Journal - CHEM-EUR J , 2010

T5.4 Blood flow volume changes in the fetoplacental circulation during normal pregnancy

Journal: Cancer Letters - CANCER LETT , vol. 1, pp. S16-S16, 2010

Serum autoantibodies as biomarkers for early cancer detection (Citations: 11)

, , ,

Journal: Febs Journal - FEBS J , vol. 276, no. 23, pp. 6880-6904, 2009

Glycoproteomic analysis of two mouse mammary cell lines during transforming growth factor (TGF)-β induced epithelial to mesenchymal transition (Citations: 5)

, , , , ,

Journal: Proteome Science - PROTEOME SCI , vol. 7, no. 1, pp. 2-17, 2009

Keywords (7)

Targeting the neural cell adhesion molecule in cancer,10.1016/j.canlet.2007.09.004,Cancer Letters,Markus Jensen,Frank Berthold

Citation Context (2)

Jennifer J Hill, et al. Glycoproteomic analysis of two mouse mammary cell lines during transfo...

Silvia Zecchini, et al. Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms

References (60)

Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis (Citations: 26)

Multitasking in Tumor Progression: Signaling Functions of Cell Adhesion Molecules (Citations: 36)

Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily (Citations: 131)

Intracellular Signaling by the Neural Cell Adhesion Molecule (Citations: 27)

Zippers Make Signals: NCAM-mediated Molecular Interactions and Signal Transduction (Citations: 71)