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The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women

The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women,10.1016/j.canlet.2007.11.029,Cancer Letters,Anna Jakub

The VEGF_936_C>T 3′UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women   (Citations: 8)
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The vascular endothelial growth factor (VEGF) plays a crucial role in the initiation of angiogenesis, which is an important stage in tumor development. A functional 936_C>T polymorphism in the VEGF gene and its association with sporadic breast cancer risk has been analyzed in various studies yielding conflicting results. To analyze the role of this polymorphism in modifying hereditary breast and ovarian cancer risks, we conducted a case–control study and genotyped 755 Polish BRCA1 carriers, including 319 breast cancer cases, 146 ovarian cancer cases, and 290 unaffected controls. The results revealed an association of the CT+TT genotypes with a reduced breast cancer risk (ORadj 0.63, 95% CI, 0.41–0.98; ORclustered 0.63, 95% CI, 0.48–0.83), and a potential effect on ovarian cancer risk (ORadj 0.62, 95% CI, 0.33–1.18; ORclustered 0.62, 95% CI, 0.47–0.83). Thus, the 936_C>T polymorphism appears to modify disease risks in BRCA1 carriers.
Journal: Cancer Letters - CANCER LETT , vol. 262, no. 1, pp. 71-76, 2008
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    • ...Jacob et al. [18] Caucasian Postmenopausal breast cancer 488/489 360 128 363 126 Jakubowska et al. [19] Caucasian BRCA1 mutated breast cancer 319/290 245 74 202 88...
    • ...Krippl et al. [16] reported that carriers of a VEGF 936T allele are at decreased risk for breast cancer (OR = 0.51, 95% CI 0.38‐0.70) in 500 women with breast cancer and 500 sex- and age-matched healthy control subjects, and Jakubowska et al. [19] also reported that VEGF 936T allele appears to decrease breast cancer risks in BRCA1 carriers...

    Dae Sik Yanget al. Association of a vascular endothelial growth factor gene 936 C/T polym...

    • ...and increased risk for BC [9, 10] in some reports...
    • ...In contrast, the wild 936CC genotype was associated with increased risks for BC in the studies conducted by Krippl et al. [9] in Austria and Jakubowska et al. [10] in Poland...
    • ...Jakubowska et al. [10] analyzed only carriers of the BRCA1 mutation and therefore, conducted a particular study...

    Cristiane Oliveiraet al. Polymorphisms in the 5′- and 3′-untranslated region of the VEGF gene a...

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