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Apical membrane localization of glycogen synthase kinase 3β protein in normal colon epithelium and aberrant distribution in colorectal cancer

Apical membrane localization of glycogen synthase kinase 3β protein in normal colon epithelium and aberrant distribution in colorectal cancer,10.1016/

Apical membrane localization of glycogen synthase kinase 3β protein in normal colon epithelium and aberrant distribution in colorectal cancer  
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Glycogen synthase kinase 3β (GSK-3β) was subsequently shown to function in a wide range of cellular processes. GSK-3β is a multifunctional serine/threonine kinase which performs a role in several signaling pathways including Wnt signal transduction. Recently, the activity of membrane-localized GSK-3β has been shown to be crucial for initiation of Wnt cascade. In our study, the membrane localization of GSK-3β was found on the apical membrane of normal epithelium, where co-localized and directly bound with MUC1. In colorectal cancer, depolarized cells showed the aberrant distribution of GSK-3β on the cellular membrane with β-catenin nuclear accumulation. The aberrant distribution of the membrane-localized GSK-3β may contribute to the development of colorectal cancer.
Journal: Cancer Letters - CANCER LETT , vol. 275, no. 1, pp. 158-162, 2009
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