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Dysregulation of cellular signaling in gastric cancer

Dysregulation of cellular signaling in gastric cancer,10.1016/j.canlet.2010.04.025,Cancer Letters,William K. K. Wu,Chi H. Cho,Chung W. Lee,Daiming Fan

Dysregulation of cellular signaling in gastric cancer   (Citations: 3)
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The pathogenesis of gastric cancer is complex and related to multiple factors. Dysregulation of intracellular signaling pathways represents a common pathogenic mechanism and may be amenable to drug targeting. Multiple well-established oncogenic pathways, such as those mediated by cell cycle regulators, nuclear factor-κB, cyclooxygenase-2 and epidermal growth factor receptor are implicated in gastric carcinogenesis. Emerging evidence also underscores the importance of signaling pathways involved in the developmental process, including transforming growth factor-β/bone morphogenetic protein signaling, Wnt/β-catenin signaling, Hedgehog signaling and Notch signaling. Understanding their biological significance will provide a rational basis for drug development. Their relative importance and cross-talk in gastric carcinogenesis, however, are still not completely understood and warrant further investigation.
Journal: Cancer Letters - CANCER LETT , vol. 295, no. 2, pp. 144-153, 2010
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    • ...It is well known that cells metabolize arachidonic acid to prostaglandins and thromboxanes by the cyclooxygenases COX-1 and COX-2 [39] and thromboxane level is generally considered a measure of cyclooxigenases activity [40]...
    • ...The implication in gastric carcinogenesis of oncogenic pathways such as those mediated by cyclin D and cyclin E, nuclear factor-kB, cyclooxygenase-2, and epidermal growth factor is well established, while recent evidences have highlighted the importance of signalling pathways involved in developmental processes, including Wnt/b-catenin signalling, Hedgehog and Noch signalling [39]...
    • ...This hypothesis is in line with recent views on the pivotal role of dysregulation of cell signalling in the aetiology of gastric cancer [39]...

    Francesca Marconet al. Gene expression in response to ionizing radiation and family history o...

    • ...Pathological study showed that COX-2 gene expression increased in gastric tumor tissue, but not in normal gastric mucosa [10, 11], which suggested that COX-2 expression could be related to tumor invasion and metastasis...

    Dan MaMinet al. Cycloxygenase-2 is Essential for the Survival and Proliferation of Gas...

    • ...Largescale multidisciplinary investigations on gastric cancer have indicated that gastric cancer is a multiple gene disease and a series of molecules are involved in gastric cancer carcinogenesis [5, 6]. Nevertheless, relatively little is known about how specific molecules are involved in the...

    Zhibo Houet al. MicroRNA146a is down-regulated in gastric cancer and regulates cell pr...

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