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Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety

Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Ca

Randomized Trial of Radiotherapy Versus Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy in Patients With American Joint Committee on Cancer/International Union Against Cancer Stage III and IV Nasopharyngeal Cancer of the Endemic Variety   (Citations: 97)
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Journal: Journal of Clinical Oncology - J CLIN ONCOL , vol. 23, no. 27, pp. 6730-6738, 2005
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    • ...High dose RT of ≥ 66 Gy in combination with chemotherapy has yielded a 5-year locoregional control for more than 80% of the patients with locally advanced disease [1-3]...

    Janjira Petsuksiriet al. Sensorineural hearing loss after concurrent chemoradiotherapy in nasop...

    • ...a first-line treatment in patients with nasopharyngeal carcinoma, and switching from cisplatin to carboplatin whenever the patients developed renal or serious toxicities from cisplatin [1,13-18]...
    • ...cisplatin regimen showed there was a wide range of responses between 49% to 98% [13,17,23-25]...
    • ...The three-year overall survival rate and progression-free survival rate in nasopharyngeal carcinoma patients who received concurrent chemoradiotherapy with cisplatin were 71-89%, and 54-88%, respectively [10,17,21]...

    Tanadech Dechaphunkulet al. Concurrent chemoradiotherapy with carboplatin followed by carboplatin ...

    • ...Radiotherapy with or without simultaneous chemotherapy according to stage is the standard of care for primary nasopharyngeal cancer resulting in excellent local control and overall survival rates [1-6]...
    • ...from primary advanced nasopharyngeal cancer [1-6]...
    • ...Concurrent chemotherapy has been shown to improve response, local control and overall survival compared to radiotherapy alone in the treatment of primary nasopharyngeal cancer in many series and is now accepted as the standard of care for advanced primary lesions [1-6]...

    Falk Roederet al. Intensity modulated or fractionated stereotactic reirradiation in pati...

    • ...Chemotherapy delivered concurrently with conventional radiotherapy has been shown to improve local control, disease-free survival, as well as overall survival rates for NPC patients with T2B, T3 or T4 diseases, or with neck lymphadenopathy [1-5]...
    • ...Although the efficacy of chemotherapy used in concomitant with conventional radiation therapy has been repeatedly proven [1-5], the additive value of concurrent chemotherapy on local/regional control and survival rates for locoregionally advanced NPC treated with IMRT is largely unknown...
    • ...Similar results on treatment-induced complications have been documented in randomized and retrospective studies [2-4,16]...
    • ...These favorable results were subsequently confirmed by a number of randomized clinical trials completed in Asia and a meta-analysis [2-5]...

    Shaojun Linet al. Sequential chemotherapy and intensity-modulated radiation therapy in t...

    • ...Several studies have shown the superiority of CCRT followed by adjuvant chemotherapy over RT alone, especially to control distant metastasis [hazard ratio (HR) = 0.57] [5, 6]. However, patient compliance with adjuvant chemotherapy has been problematic; up to 15% of patients did not receive planned adjuvant chemotherapy, due to toxicity and patient refusal...

    Woo Kyun Baeet al. Phase II study of docetaxel, cisplatin, and 5FU induction chemotherapy...

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