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Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease,10.1111/j.1365-2613.2007.00568.x,International Jo

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease   (Citations: 13)
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Journal: International Journal of Experimental Pathology - INT J EXP PATHOL , vol. 89, no. 2, pp. 81-90, 2008
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    • ...Recently, remarkable studies characterizing tau truncation in AD brain tissues have appeared [4, 9, 13, 19, 23]...
    • ...The density of truncated tau correlates with both the clinical dementia index and Braak staging in AD patients [4, 19]...
    • ...In postmortem AD patient brain tissues [19], a large number of phospho-tau positive neurons were detected in absence of truncated tau, which agrees that tau phosphorylation appears earlier...

    Qipeng Zhanget al. Truncated tau at D421 is associated with neurodegeneration and tangle ...

    • ...The bulk of data that have been found recently has demonstrated that the molecular mechanisms involved in tau processing in AD leading to PHF formation are driven by two physical events: aggregation and polymerization [26– 29] . These two events appear to be related to time and the following of specific molecular mechanisms that include steps in which abnormal phosphorylations and truncation processes play a major role [22, 30] . These ...

    Raúl Menaet al. Stages of Pathological Tau-Protein Processing in Alzheimer’s Disease: ...

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