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Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol

Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol,10.1002/cncr.24

Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol   (Citations: 4)
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Journal: Cancer , vol. 116, no. 3, pp. 705-712, 2010
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    • ...For pediatric patients, there is evidence that survival is better when complete surgical resection is possible [9], and intensive chemotherapy is beneficial in those who undergo complete surgical resection [10]...
    • ...In the third protocol (HIT GBM-C) we evaluated continuous treatment with the same type of this intensive chemotherapy [10, 24] followed by the histone deacetylase inhibitor valproic acid [25]...
    • ...Essentially unchanged from previous HIT-GBM protocols, the main eligibility criterion was a diagnosis of either histological proven HGG (WHO grade III or IV) or DIPG [10, 23, 24]...
    • ...Two weeks after the second MTX, traditional induction with simultaneous radiochemotherapy followed using the previous HIT-GBM-C protocol [10, 22]...
    • ...These 30 patients were distinct from the 310 patients recently described in detail [10, 24], who had been registered in the HIT-GBM cohort comparison study until the end of the enrollment in March 2003...
    • ...The control group consisted of the 310 patients previously described [10, 24] plus 20 patients, who were treated following other protocols without MTX at the same time as HIT-GBM-D-pilot was running but consented and registered to our database as observation patients...
    • ...The feasibility of that protocol had been described well [10, 24, 25], and our concern was that adding MTX before radiotherapy might not only result in immediate toxicity but also increase the toxicity of the subsequent simultaneous treatment...
    • ...8 achieved CR, 33 achieved PR, 127 had SD, and 63 had PD. This included the 19% (14 of 75) responders in protocol HIT-GBM-C [10], compared to 11/24 (46%) in the treatment group...
    • ...The two previous protocols with similar results were HIT-91-S [18] and HIT-GBM-C [10], while data of two other protocols in the same multicenter group could not confirm the finding [20, 23]...

    Johannes E. WolffRolf-Dieteret al. High dose methotrexate for pediatric high grade glioma: results of the...

    • ...This list includes drugs that were not successful when tested as first-line treatments for pontine glioma [27]; however, DIPG are not the same tumors when they recur...

    Johannes E. Wolffet al. Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anders...

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