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Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols

Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols,10.1002/jmri.22024,Journal of Magnetic Re

Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols   (Citations: 9)
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Journal: Journal of Magnetic Resonance Imaging - J MAGN RESON IMAGING , vol. 31, no. 2, pp. 440-446, 2010
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    • ...had diminished since the implementation of preventative measures [21]...

    Colleen M. Costelloeet al. Comparison of half-dose and full-dose gadolinium MR contrast on the en...

    • ...Many methods are used for MRA of the lower limbs. This analysis suggests that the three broad approaches – multiple injections for each anatomical field, a bolus chase method when a single infusion of contrast is followed down the legs or a hybrid of these techniques result in similar accuracy. A major limitation is venous contamination, in other words, obscuration of the calf arteries by venous enhancement. This limitation will be less obvious in pooled headline figures that do not distinguish between the performance of MRA at different anatomical segments. The analysis does separate performance in different parts of the arterial tree and does show lower sensitivity and specificity in the calf, but the significance of this difference is not calculated. MRA continues to evolve, and the use of techniques such as thigh compression cuffs or rapid time resolved imaging of the calves substantially reduces venous contamination. There is also a recent re-emergence of non-contrast MRA on commercial MR systems. In a financially pressured environment, this may yet replace contrast-enhanced MRA. Nephrogenic systemic fibrosis (NSF) is a potential complication of the use of gadolinium agents. However, the risk is stratified depending on the agent used, and a recent study showed that change to a lower risk agent results in marked reduction in NSF in patients on dialysis....

    Paul N Malcolmet al. Prospective studies show that magnetic resonance angiography has high ...

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