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Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial

Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised cont

Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial   (Citations: 23)
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Journal: Lancet Neurology - LANCET NEUROL , vol. 9, no. 1, pp. 39-45, 2010
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    • ...Meta-analysis of these trials indicates that TH reduces the risk of adverse outcome by approximately 15%, with a number-needed to treat of 6-8 infants(5-7)...
    • ...Following the publication of the above evidence, cooling for infants with NE has been recommended or adopted as a standard of care in neonatal units in some countries(8-10)...
    • ...The majority of deaths in infants with HIE in neonatal units in developed countries follow decisions to withdraw treatment in the face of predicted poor prognosis(3,8,37,38)...
    • ...Infants who were cooled were less likely to have MRI evidence of injury, or had less severe patterns of injury, but those who had such patterns were still likely to have a poor outcome(48)...

    Dominic J. Wilkinsonet al. Ethical challenges in the use of therapeutic hypothermia in Indian neo...

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