Keywords (1)

Academic
Publications
How do NK cells sense the expression of HLA-G class Ib molecules?

How do NK cells sense the expression of HLA-G class Ib molecules?,10.1006/scbi.1998.0107,Seminars in Cancer Biology,Miguel López-Botet,Francisco Navar

How do NK cells sense the expression of HLA-G class Ib molecules?   (Citations: 22)
BibTex | RIS | RefWorks Download
The nature of NK cell receptors involved in recognition of HLA-G1 has remained an unclear issue; we herein review this topic based on our experience. We found no evidence that well characterized p58 and p70 KIRs may interact with HLA-G1. By contrast, our data support that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor–ligand systems: (1) the direct engagement of the ILT2 (LIR1) receptor by HLA-G1; and (2) the interaction of CD94/NKG2A and CD94/NKG2C receptors with the non-classical class I molecule HLA-E, co-expressed on the surface upon binding to a nonamer (VMAPRTLFL) from the HLA-G leader sequence.
Journal: Seminars in Cancer Biology - SEMIN CANCER BIOL , vol. 9, no. 1, pp. 19-26, 1999
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: