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Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer

Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer,10.1136/jcp.2005.028209,Journal of Clinical Pathology,M Burk

Cytoplasmic overexpression of ALCAM is prognostic of disease progression in breast cancer   (Citations: 27)
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Journal: Journal of Clinical Pathology - J CLIN PATHOL , vol. 59, no. 4, pp. 403-409, 2006
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    • ...Regarding metastases and prognosis, the role of ALCAM seems to be double-edged: on the one hand, ALCAM downregulation may facilitate the detachment of tumour cells from the main tumour mass, gaining access to metastatic routes due to reduced adhesion. On the other hand, studies on melanomas, colorectal cancer, oesophageal tumours, pancreatic and oral carcinomas have shown associations of ALCAM overexpression and poor prognosis, which may be due to increased ALCAM-mediated adherence of metastatic tumour cells to distant organs after detachment from the primary tumour....

    Maike Ihnenet al. Protein expression analysis of ALCAM and CEACAM6 in breast cancer meta...

    • ...Altered ALCAM expression has been suggested as prognostic indicator in breast carcinoma but some discrepancy exists as to whether low ALCAM mRNA expression [29] or high ALCAM protein expression [30] is a bad prognostic indicator...
    • ...This is in agreement with published results [29, 37] but not with data showing that increased cytoplasmic ALCAM expression is linked to higher tumour grading [30]...
    • ...This is supported by data reporting that one monoclonal antibody gave opposite results on frozen tissue [29] compared to formaldehyde fixed tissue [30]...

    Merete Thune Wiigeret al. A novel human recombinant single-chain antibody targeting CD166/ALCAM ...

    • ...With respect of its prognostic value, however, contradictory results have been published, indicating that strong ALCAM expression might be either a marker of a favorable prognosis [13, 14 ]o r of a highly aggressive tumor type [15]...
    • ...In contrast to these results, an immunohistochemical study [15] found out that high cytoplasmic ALCAM expression as found in 17% of cases was significantly associated with earlier disease progression and shortened DFS...
    • ...Our study did not confirm the results of the immunohistochemical study [15] if the patients were stratified according to Tamoxifen treatment...

    M. Ihnenet al. Predictive impact of activated leukocyte cell adhesion molecule (ALCAM...

    • ...The IRS (negative (-), 0~2; weak positive (+), 3~4; positive (++), 5~6; strong positive (+++), >7) was the product of staining intensity (graded between 0 and 3) and the percentage of positive cells (graded between 0 and 4: 0, ≤5%; 1, 6%~25%; 2, 26%~50%; 3, 51%~75%; 4, ≥75%) [11]...

    Hua Chenet al. Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibit...

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