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Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis

Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis,10.1016/j.rmed.2008.06.005,Respiratory Medicine,G. A. Anwar,S. C. Bo

Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis   (Citations: 15)
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Journal: Respiratory Medicine - RESP MED , vol. 102, no. 10, pp. 1494-1496, 2008
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    • ...Antimicrobial therapy, mostly antibiotics, has been tried systemically and via inhalation. When systemic antibiotics are used, strategies applied differ greatly. Sometimes they are used as needed or schematically, alternating one or more antibiotics. Overall, chronic antibiotic treatment is currently not recommended. There is one exception: macrolide therapy. Owing to their non-antibiotic effect on bronchiectatic inflammation, the use of macrolides is very interesting. Total BAL cell count, sputum volume, interleukin (IL)-8 and neutrophils all seem to decrease with macrolide use. Patients with frequent exacerbations of NCFB who had been treated with rescue antibiotics showed an improvement in exacerbation frequency, spirometry and sputum microbiology when treated with azithromycin 250 mg three times a week....

    Pieter Goeminneet al. Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st c...

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