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Development of Integrated Backscatter Intravascular Ultrasound for Tissue Characterization of Coronary Plaques

Development of Integrated Backscatter Intravascular Ultrasound for Tissue Characterization of Coronary Plaques,10.1016/j.ultrasmedbio.2007.09.015,Ultr

Development of Integrated Backscatter Intravascular Ultrasound for Tissue Characterization of Coronary Plaques   (Citations: 9)
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Munenori Okubo, Masanori Kawasaki, Yoshiyuki Ishihara, Urara Takeyama, Tomoki Kubota, Takahiko Yamaki, Shinsuke Ojio, Kazuhiko Nishigaki, Genzou Takemura, Masanao Saio, Tsuyoshi Takami, Shinya Minatoguchihttp://academic.research.microsoft.com/io.ashx?type=5&id=31099211&selfId1=0&selfId2=0&maxNumber=12&query=
Tissue characterization of plaques of coronary arteries is important to clarify the process of acute coronary syndrome and prevent it. The purpose of this study is to develop an online integrated backscatter intravascular ultrasound (IB-IVUS) system and validate the diagnostic accuracy for the characterization of coronary plaques. A personal computer equipped with custom software was connected to an IVUS imaging system. Images were acquired from 242 segments of 46 coronary arteries from 25 cadavers obtained at autopsy. In the training study, a total of 724 regions-of-interests on color-coded maps were compared with histologic images. In the validation study, a total of 192 cross-sections of coronary arteries were evaluated. Receiver operating characteristic curve analysis showed that the cut-off points of −49 dB (area under curve = 0.98) and −29 dB (area under curve = 0.99) were the most reliable predictors of lipid pools, fibrosis and calcification. In the validation study, the analysis using IB values classified fibrous, lipid-rich and fibrocalcific plaque components with a high accuracy of 93%, 90% and 96%, respectively. The overall agreement between histologic and IB-IVUS diagnoses (n = 175) was high (Cohen’s κ = 0.81). The IB-IVUS system provides high diagnostic accuracy for analysis of tissue characteristics of coronary plaques. (E-mail: masanori@ya2.so-net.ne.jp)
Journal: Ultrasound in Medicine and Biology - ULTRASOUND MED BIOL , vol. 34, no. 4, pp. 655-663, 2008
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    • ...Meanwhile, this limitation has been partially overcome by new innovative IVUS-based post-processing methods such as: virtual histology IVUS [15, 16] (VH-IVUS, Volcano Therapeutics, Rancho Cordova, CA, USA), iMAP-IVUS [17] (Bostoc Scientific, Santa Clara, CA, USA), Integrated Backscatter IVUS [18] (IB-IVUS) and Automated Differential Echogenicity [19] (ADE)...
    • ...Okubo [18] Ex vivo 2008 Development of integrated backscatter intravascular ultrasound for tissue characterization of coronary plaques IB classified fibrous, lipid-rich and fibrocalcific plaque components with a high accuracy of 93, 90 and 96%, respectively iMAP...
    • ...It comprises the following different tissue components: (1) Calcification, (2) Fibrous tissue, and (3) Lipidic [18, 22, 23]...

    Hector M. Garcìa-Garcìaet al. IVUS-based imaging modalities for tissue characterization: similaritie...

    • ...Due to considerable overlap of IB values for lipid pool and intimal hyperplasia, a more recent analysis by the same group excluded intimal hyperplasia as a category; they did fi nd, however, sensitivity and specifi city very similar to their previous analysis [31]...

    Michael A. Gaglia Jret al. Intravascular ultrasound: Virtual histology IVUS, integrated backscatt...

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