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Markers of Oxidative Damage Are Not Elevated in Otherwise Healthy Individuals With the Metabolic Syndrome

Markers of Oxidative Damage Are Not Elevated in Otherwise Healthy Individuals With the Metabolic Syndrome,10.2337/dc09-2124,Diabetes Care,R. C. S. See

Markers of Oxidative Damage Are Not Elevated in Otherwise Healthy Individuals With the Metabolic Syndrome   (Citations: 5)
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Journal: Diabetes Care , vol. 33, no. 5, pp. 1140-1142, 2010
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    • ...Several previous studies have demonstrated that elevated CRP was associated with increased odds of MetS after adjusting for potential confounding factors [23-26]...

    Ryuichi Kawamotoet al. High-sensitivity c-reactive protein and gamma-glutamyl transferase lev...

    • ...Other studies show no difference in oxidised LDL levels [8 ]o r markers of oxidative damage (plasma F2-isoprostanes, hydroxy-eicosatetraenoic acid [HETE]) [9 ]b etween patients with the metabolic syndrome and healthy individuals...
    • ...In addition, most studies have focused on lipid peroxides issued from the non-enzymatic peroxidation of arachidonic acid [7, 9]. Paradoxically, no data (to our knowledge) are available on circulating lipid peroxides issued from linoleic acid, although it is the main polyunsaturated fatty acid (PUFA) in LDL...
    • ...Conversely, there were no changes in total HETE concentrations in metabolic syndrome patients, which is in agreement with a recent study showing no differences in the levels of oxidation products of arachidonic acid (total HETE and F2-isoprostanes) in individuals with features of metabolic syndrome [9]...
    • ...Although isoprostanes are recognised as reliable markers of oxidative stress in vivo, they derive exclusively from the free radical-induced peroxidation of arachidonic acid and their levels were either reported to be increased [7] or unchanged [9] in patients with the metabolic syndrome...

    R. Colaset al. LDL from obese patients with the metabolic syndrome show increased lip...

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