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Cytotoxicity of 111In-oxine on mesenchymal stem cells: a time-dependent adverse effect

Cytotoxicity of 111In-oxine on mesenchymal stem cells: a time-dependent adverse effect,10.1097/MNM.0b013e328318b328,Nuclear Medicine Communications,Al

Cytotoxicity of 111In-oxine on mesenchymal stem cells: a time-dependent adverse effect   (Citations: 7)
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Journal: Nuclear Medicine Communications - NUCL MED COMMUN , vol. 30, no. 3, pp. 210-216, 2009
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    • ...labeling [68]. To abrogate these effects, it has been suggested that only a fraction of the SC population be labelled [69]...

    Alessandro Ruggieroet al. Cell tracking in cardiac repair: what to image and how to image

    • ...In the case of radioactive labelling, the toxicity might be due both to the radiation exposure [21, 22] and to the carrier itself (e.g...
    • ...radiation [21, 22], while oxine toxicity is already a wellknown phenomenon [23]...

    Luisa Ottobriniet al. In vivo imaging of immune cell trafficking in cancer

    • ...In our previous experience [2], we incubated mesenchymal stem cells with different dosages of 111 In-Oxine...
    • ...We cannot exclude the possibility that radionuclide signals are detected from the reticuloendothelial cells, which theoretically are able to phagocytize nonviable stem cells (for example, due to time-dependent cytotoxic effect of the 111 In-oxine, after infusion, a limited portion of stem cells will lose viability [2])...

    Ali Gholamrezanezhad. Letter to the Editor: Emerging Approaches for Cardiovascular Stem Cell...

    • ...viability and proliferation capacity of the labelled cells [16, 22, 23], which may furthermore depend on the cell type...
    • ...In addition, present findings highlight the time dependence of cytotoxic effects, in agreement with earlier studies showing a dramatic decrease in cell viability primarily, between 2 and 7 days after 111 In- oxine labelling [22]...
    • ...A dose-dependent long-term cytotoxic effect was likewise reported by Gholamrezanezhad et al., with cell death of 80% upon incubation with 7 MBq [22]...

    Franz Josef Gildehauset al. Impact of Indium111 Oxine Labelling on Viability of Human Mesenchymal ...

    • ...Therefore, assessment of stem cell viability immediately after radioactive labeling may fail to detect cytotoxic effects of this radiopharmaceutical on stem cell integrity [28]...

    Yingli Fuet al. Tracking of Stem Cells In Vivo

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