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Dendritic cell vaccination and immune monitoring

Dendritic cell vaccination and immune monitoring,10.1007/s00262-008-0553-y,Cancer Immunology Immunotherapy,E. H. J. G. Aarntzen,C. G. Figdor,G. J. Ade

Dendritic cell vaccination and immune monitoring   (Citations: 18)
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We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC.
Journal: Cancer Immunology Immunotherapy - CANCER IMMUNOL IMMUNOTHER , vol. 57, no. 10, pp. 1559-1568, 2008
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