Neoplastic stem cells: Current concepts and clinical perspectives

Neoplastic stem cells: Current concepts and clinical perspectives,10.1016/j.critrevonc.2010.01.001,Critical Reviews in Oncology Hematology,Axel Schule

Neoplastic stem cells: Current concepts and clinical perspectives   (Citations: 2)
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Axel Schulenburg, Kira Brämswig, Harald Herrmann, Heidrun Karlic, Irina Mirkina, Rainer Hubmann, Sylvia Laffer, Brigitte Marian, Medhat Shehata, Clemens Krepler, Hubert Pehamberger, Thomas Grunt
Neoplastic stem cells have initially been characterized in myeloid leukemias where NOD/SCID mouse-repopulating progenitors supposedly reside within a CD34+/Lin− subset of the malignant clone. These progenitors are considered to be self-renewing cells responsible for the in vivo long-term growth of neoplastic cells in leukemic patients. Therefore, these cells represent an attractive target of therapy. In some lymphoid leukemias, NOD/SCID mouse-repopulating cells were also reported to reside within the CD34+/Lin− subfraction of the clone. More recently, several attempts have been made to transfer the cancer stem cell concept to solid tumors and other non-hematopoietic neoplasms. In several of these tumors, the cell surface antigens AC133 (CD133) and CD44 are considered to indicate the potential of a cell to initiate permanent tumor formation in vivo. However, several questions concerning the phenotype, self-renewal capacity, stroma-dependence, and other properties of cancer- or leukemia-initiating cells remain to be solved. The current article provides a summary of our current knowledge on neoplastic (cancer) stem cells, with special emphasis on clinical implications and therapeutic options as well as a discussion about conceptual and technical limitations.
Journal: Critical Reviews in Oncology Hematology - CRIT REV ONCOL HEMATOL , vol. 76, no. 2, pp. 79-98, 2010
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    • ...CSC are undifferentiated cells characterised by three major features: (1) potential to differentiate into several or all types of cells that are produced by the original tumour; (2) self - renewal ability; and (3) capacity to maintain the ‘stem cell pool’ and the most mature tumour elements for unlimited time periods [5]...
    • ...These antigens might include regular stem cells antigens such as cytokine receptors, homing receptors (integrins, selectin-ligands, chemokine receptors, cytoadhesion molecules and ligands of matrix molecules such L1 or CD44) and various drug transporters [5,6]...

    Sandra Kraljevic Pavelicet al. Metastasis: new perspectives on an old problem

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