Academic
Publications
Neoplastic stem cells: Current concepts and clinical perspectives

Neoplastic stem cells: Current concepts and clinical perspectives,10.1016/j.critrevonc.2010.01.001,Critical Reviews in Oncology Hematology,Axel Schule

Neoplastic stem cells: Current concepts and clinical perspectives   (Citations: 2)
BibTex | RIS | RefWorks Download
Axel Schulenburg, Kira Brämswig, Harald Herrmann, Heidrun Karlic, Irina Mirkina, Rainer Hubmann, Sylvia Laffer, Brigitte Marian, Medhat Shehata, Clemens Krepler, Hubert Pehamberger, Thomas Grunthttp://academic.research.microsoft.com/io.ashx?type=5&id=31491322&selfId1=0&selfId2=0&maxNumber=12&query=
Neoplastic stem cells have initially been characterized in myeloid leukemias where NOD/SCID mouse-repopulating progenitors supposedly reside within a CD34+/Lin− subset of the malignant clone. These progenitors are considered to be self-renewing cells responsible for the in vivo long-term growth of neoplastic cells in leukemic patients. Therefore, these cells represent an attractive target of therapy. In some lymphoid leukemias, NOD/SCID mouse-repopulating cells were also reported to reside within the CD34+/Lin− subfraction of the clone. More recently, several attempts have been made to transfer the cancer stem cell concept to solid tumors and other non-hematopoietic neoplasms. In several of these tumors, the cell surface antigens AC133 (CD133) and CD44 are considered to indicate the potential of a cell to initiate permanent tumor formation in vivo. However, several questions concerning the phenotype, self-renewal capacity, stroma-dependence, and other properties of cancer- or leukemia-initiating cells remain to be solved. The current article provides a summary of our current knowledge on neoplastic (cancer) stem cells, with special emphasis on clinical implications and therapeutic options as well as a discussion about conceptual and technical limitations.
Journal: Critical Reviews in Oncology Hematology - CRIT REV ONCOL HEMATOL , vol. 76, no. 2, pp. 79-98, 2010
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...CSC are undifferentiated cells characterised by three major features: (1) potential to differentiate into several or all types of cells that are produced by the original tumour; (2) self - renewal ability; and (3) capacity to maintain the ‘stem cell pool’ and the most mature tumour elements for unlimited time periods [5]...
    • ...These antigens might include regular stem cells antigens such as cytokine receptors, homing receptors (integrins, selectin-ligands, chemokine receptors, cytoadhesion molecules and ligands of matrix molecules such L1 or CD44) and various drug transporters [5,6]...

    Sandra Kraljevic Pavelicet al. Metastasis: new perspectives on an old problem

Sort by: