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Shedding of Distinct Cryptic Collagen Epitope (HU177) in Sera of Melanoma Patients

Shedding of Distinct Cryptic Collagen Epitope (HU177) in Sera of Melanoma Patients,10.1158/1078-0432.CCR-07-4992,Clinical Cancer Research,B. Ng,J. Zak

Shedding of Distinct Cryptic Collagen Epitope (HU177) in Sera of Melanoma Patients   (Citations: 6)
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B. Ng, J. Zakrzewski, M. Warycha, P. J. Christos, D. F. Bajorin, R. L. Shapiro, R. S. Berman, A. C. Pavlick, D. Polsky, M. Mazumdar, A. Montgomery, L. Liebeshttp://academic.research.microsoft.com/io.ashx?type=5&id=31679278&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Clinical Cancer Research - CLIN CANCER RES , vol. 14, no. 19, pp. 6253-6258, 2008
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    • ...We have successfully developed an ELISA assay to detect and quantify levels of cryptic epitope HU177 in the serum of melanoma patients and demonstrated that the level of HU177 correlated with tumor thickness and with the nodular histologic subtype [10]...
    • ...Previously published results demonstrated that time of collection does not influence the relationship between HU177 level and tumor characteristics [10]...
    • ...HU177 cryptic epitope concentration (ng/ml) was quantified by a capture assay described in detail previously [10]...
    • ...the concentration of cryptic epitope in patient samples was extrapolated [10]...
    • ...HU177 values were dichotomized into two groups using the mean (6.2 ng/ml) and median (3.7 ng/ml) values determined previously in this cohort [10]...

    Heather K Hamiltonet al. Increased shedding of HU177 correlates with worse prognosis in primary...

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