The Impact of Fish Oil on the Chemopreventive Efficacy of Tamoxifen against Development of N-Methyl-N-Nitrosourea-Induced Rat Mammary Carcinogenesis

...We have recently reported that a combination of a fish oil (FO)-rich diet and Tamoxifen inhibited N-methyl-Nnitrosourea (MNU)-induced rat mammary carcinogenesis to a greater extent than the individual interventions [6]...
...Fatty Acid Analysis in the Diets, Plasma, and Tumors Identification and quantification of the total plasma and tumor fatty acids were determined by gas chromatography equipped with flame ionization detection using authentic standards as described previously [6, 13]...
...previously observed by us [6] and other investigators [15, 16] and shown not to reflect toxicity from the drug...
...In the second experiment, we used a dose of Tamoxifen of 1 ppm that has suboptimal antiestrogenic and antitumor effect and a dose of FO of 17%, which we found potentiated the chemopreventive action of Tamoxifen in a prepubertal model of MNU-induced rat mammary carcinogenesis [6]...
...potentiated the chemopreventive action of Tamoxifen [6]...

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