Oral spindle cell lipoma,10.1053/adpa.2001.26973,Annals of Diagnostic Pathology,Nasser Said-Al-Naief,Fazlur R. Zahurullah,James J. Sciubba

• ...DiVerent histopathological variants have been described [1, 2]. Although lipomas are one of the most common mesenchymal neoplasms [1–3], the head and neck regions are aVected in 20% of cases [2] and only 1–4% of these tumors are located in the oral cavity [4, 5]...
• ...Clinically, these tumors manifest as asymptomatic, slow-growing, and submucosal nodules [2, 6]. The most aVected anatomical sites in the oral cavity include the buccal mucosa, lips, and tongue [1, 2, 6]. The Xoor of the mouth [3, 6], palate [3, 7], retromolar pad [1, 6], and salivary glands [6] are less frequently involved...
• ...Clinically, these tumors manifest as asymptomatic, slow-growing, and submucosal nodules [2, 6]. The most aVected anatomical sites in the oral cavity include the buccal mucosa, lips, and tongue [1, 2, 6]. The Xoor of the mouth [3, 6], palate [3, 7], retromolar pad [1, 6], and salivary glands [6] are less frequently involved...
• ...The following histopathological variants of lipomas have been described: Wbrolipoma, osteolipoma, chondrolipoma, intramuscular lipoma, angiolipoma, angiomyolipoma, myolipoma, myelolipoma, chondroid lipoma, spindle cell lipoma, pleomorphic lipoma, and sialolipoma [1, 8, 9]. Treatment of lipomas consists of simple surgical removal, irrespective of the histological subtype, with no recurrence being expected [2, 6, 10]...
• ...In contrast to the male predominance of lipomas involving other regions of the body [9], in the case of lipomas of the oral cavity, studies have demonstrated a relatively similar gender distribution [1], or a slightly higher frequency among women [6, 7, 15]...
• ...The buccal mucosa is the site most commonly aVected by oral lipomas, corresponding to 30.5–45.7% of cases [1, 3, 6, 15]...
• ...In the present study, the percentage of cases identiWed at this site (53.7%) was higher than that reported in the literature [1, 3, 6, 15]...
• ...Said-Al-Naief et al. [1] and Furlong et al. [3] identiWed the lip as the second most common location of oral lipomas, whereas in the present study, only one case (2.4%) of lipoma aVecting the lip was observed...
• ...described in the oral cavity [1, 6, 7, 10] (Table 2). Some studies have demonstrated a similar incidence of lipomas and Wbrolipomas [18–20], whereas others, like the present investigation, observed a higher proportion of lipomas [1, 5, 7, 10, 15, 21]...
• ...described in the oral cavity [1, 6, 7, 10] (Table 2). Some studies have demonstrated a similar incidence of lipomas and Wbrolipomas [18–20], whereas others, like the present investigation, observed a higher proportion of lipomas [1, 5, 7, 10, 15, 21]...
• ...The proportion of adipocytes and spindle-shaped cells is variable [1, 40, 43]...
• ...In contrast to other retrospective studies [1, 6], Furlong et al. [3] described spindle cell lipoma as the second most frequent histological variant (44.2%) in the oral cavity, with most cases involving the lip...
• ...However, no case of spindle cell lipoma in the lip was identiWed in the present investigation or in the study of Said-Al-Naief et al. [1]...

Luiz Eduardo Rodrigues Juliasse, et al. Lipomas of the oral cavity: clinical and histopathologic study of 41 c...