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Collagen arthritis as a relevant model for rheumatoid arthritis. evidence pro and con

Collagen arthritis as a relevant model for rheumatoid arthritis. evidence pro and con,10.1002/art.1780250801,Arthritis and Rheumatism,David E. Trentha

Collagen arthritis as a relevant model for rheumatoid arthritis. evidence pro and con   (Citations: 60)
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Journal: Arthritis and Rheumatism , vol. 25, no. 8, pp. 911-916, 1982
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    • ...Thus, both RA and CIA exhibit similar patterns of pannus formation, erosion of cartilage and bone, fibrosis, and ultimately, loss of articular function....

    Richard O Williamset al. Cartilage destruction and bone erosion in arthritis: the role of tumou...

    • ...For example, both RA and CIA exhibit similar patterns of synovitis, pannus formation accompanied by erosion of cartilage and bone, fibrosis, and ultimately, loss of articular function [62]...

    Richard O. Williams. Combination therapy in mice: what can we learn that may be useful for ...

    • ...The disease, which resembles human rheumatoid arthritis in many aspects [3], is not completely understood but appears to be the result of an autoimmune response to type II collagen [4]...
    • ...In addition, a large number of neutrophils are present in the joint space [1, 3, 4, 6]...

    T. Östermanet al. Effect of clodronate on established collagen-induced arthritis in rats

    • ...Immunization with native type I1 collagen induces inflammatory polyarthritis and immunity to collagen in rats and susceptible strains of mice [1, 2]. The disease, which has been shown to have similarities to human rheumatoid arthritis in many aspects [3], is a useful animal model for evaluating drug efficacy in human rheumatoid arthritis [4-6]...

    K. Takagishiet al. Effects of cyclosporin on serum hyaluronan levels in collagen arthriti...

    • ...Collagen-induced arthritis (CIA) is a model of rheumatoid arthritis (inducible in mice, rats and primates) characterized by an erosive polyarthritis following the intradermal administration of heterologous or homologous native type II collagen emulsified in complete or incomplete Freund's adjuvant [19,21,22]...
    • ...The arthritis persists for 4-8 weeks (with pannus formation) until fibrous and bony ankylosis occurs in the involved joints [22]...
    • ...Both B and T cells are important in mediating this disease since it can be passively transferred to naive recipients by serum from rats immunized with type II collagen or by lymphoeytes from collagen-sensitized animals [22-24]...
    • ...However, some dissimilarities to rheumatoid arthritis exist, including the self-limited nature of CIA, the presence of periostitis, the absence of extra-articular manifestations (except for polychondritis) and absence of rheumatoid factor [22]...

    R. L. Wong. Mechanisms of action of cyclosporin a in animal models of rheumatoid a...

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