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Effects of alcohol on the heart

Effects of alcohol on the heart,10.1097/00075198-200110000-00004,Current Opinion in Critical Care,Claudia D. Spies,Michael Sander,Karl Stangl,Joaquim

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    • ...The lifetime prevalence of alcohol abuse is estimated to be 14–24%, and one in 13 Americans currently meet criteria for alcohol dependence [1, 3]. Furthermore, from 20 to 30% of patients admitted to a general medical hospital abuse alcohol [1, 4]...
    • ...The negative effects of alcohol on human organ systems, including the heart, are well documented [1, 2, 4, 5], and persistent alcohol abuse might contribute to the onset and progression of heart failure...
    • ...Heavy alcohol consumption leads to a significantly increased risk for sudden cardiac death and cardiac arrhythmias [2, 4]. Post-operatively, in the intensive care unit, chronic alcoholics have up to five times more cardiac complications, including arrhythmias and hypoxemia, presumably due to their limited cardiac reserve [4]...
    • ...Heavy alcohol consumption leads to a significantly increased risk for sudden cardiac death and cardiac arrhythmias [2, 4]. Post-operatively, in the intensive care unit, chronic alcoholics have up to five times more cardiac complications, including arrhythmias and hypoxemia, presumably due to their limited cardiac reserve [4]...
    • ...Alcohol damage to the heart may be evident within a shorter period of time when alcohol consumption exceeds 90–100 g per day [4]...

    Christine E. Skotzkoet al. Alcohol use and congestive heart failure: incidence, importance, and a...

    • ...Morbidity and mortality consist of, but are not limited to, suicide (Wilcox, Conner, & Caine, 2004), violence (Chermack & Blow, 2002), child abuse/neglect (Harris, Lieberman, & Marans, 2007), drownings (Mitic & Greschner, 2002), house fires (Barillo & Goode, 1996), heart disease (Spies et al, 2001), hepatic dysfunction (Grando-Lemaire, Kazemi, & Trinchet, 2005), gastrointestinal neoplasms (Seitz & Meier, 2007), fetal alcohol syndrome (Sokol, Delaney-Black, & Nordstrom, 2003), peripheral neuropathy (Zambelis, Karandreas, Tzavellas, Kokotis, & Liappas, 2005), dementia (Hulse, Lautenschlager, Tait, & Almeida, 2005), and pancreatitis (Nakamura et al, 2003)...

    Raj K. Kalapatapuet al. Novel Objective Biomarkers of Alcohol Use: Potential Diagnostic and Tr...

    • ...Despite this, recent evidence has found that light to moderate amounts of alcohol may be cardioprotective against the development of sudden cardiac death and coronary artery disease, though this still remains controversial....

    J Butanyet al. Drug-related cardiac pathology

    • ...acetaldehyde toxicity, buildup of fatty acid ethyl esters, and accumulation of oxidative damage (2,3,5,6)...
    • ...Despite the fact that chronic alcohol intake interrupts cardiac protein synthesis, excitation-contraction coupling, myocardial contractile function, and responsiveness to various inotropic agents (2,3,5,6), little direct evidence has consolidated a role of oxidative damage and/or compromised antioxidant defense in alcohol-induced heart injury...
    • ...Compelling evidence from our laboratory and others has suggested that oxidative damage and loss of antioxidant defense following alcohol ingestion or ethanol exposure may contribute to cardiac excitation-contraction coupling defect (5,6,8,9)...
    • ...Parameter FVB (6) FVB+ETOH (5) MT (6) MT+ETOH (5)...
    • ...Parameter FVB (6) FVB+ETOH (5) MT (6) MT+ETOH (5)...
    • ...Light to moderate alcohol intake is beneficial to cardiac function (6)...

    Qun Liet al. Cardiac overexpression of metallothionein attenuates chronic alcohol i...

    • ...Chronic ethanol abuse can be associated with a variety of cardiovascular disorders, ranging from asymptomatic left ventricular dysfunction to hypertension, stroke, heart failure and sudden death from arrhythmias [2,41]...
    • ...The higher pulmonary capillary wedge pressure could be interpreted as a result of a higher end-diastolic pressure leading to heart failure if there were normal ventricular compliance [41]...

    Vera von Dossowet al. Altered immune parameters in chronic alcoholic patients at the onset o...

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