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CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-medicated osteoclastogenesis: Evidence of NF-κB–dependent, CD40-mediated bone destruction in rheumatoid arthritis

CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-medicated osteoclastogenesis: Evidence of NF-κB–dependent, CD40-mediated bone destruc

CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-medicated osteoclastogenesis: Evidence of NF-κB–dependent, CD40-mediated bone destruction in rheumatoid arthritis   (Citations: 20)
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Hak-Yong Lee, Hyun-Soon Jeon, Eun-Kyung Song, Myung-Kwan Han, Sung-Il Park, Sang-Il Lee, Hee-Jin Yun, Jung-Ryul Kim, Jong-Suk Kim, Yong-Chul Lee, Sung-Il Kim, Hang-Rae Kimhttp://academic.research.microsoft.com/io.ashx?type=5&id=32444546&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Arthritis and Rheumatism , vol. 54, no. 6, pp. 1747-1758, 2006
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    • ...The role of rheumatoid synovial Wbroblasts (RASFs) on osteoclastogenesis and bone destruction is further supported by the Wnding of formation of osteoclasts in co-cultures of RASFs and peripheral blood mononuclear cells (PBMCs) [3, 4]. Several factors are involved in osteoclastogenesis, including receptor activator of NF-B ligand (RANKL) [4, 5], IL-1, and TNF- which can upregulate RANKL [6, 7]. RANKL is a membranebound protein of TNF ...
    • ...The role of rheumatoid synovial Wbroblasts (RASFs) on osteoclastogenesis and bone destruction is further supported by the Wnding of formation of osteoclasts in co-cultures of RASFs and peripheral blood mononuclear cells (PBMCs) [3, 4]. Several factors are involved in osteoclastogenesis, including receptor activator of NF-B ligand (RANKL) [4, 5], IL-1, and TNF- which can upregulate RANKL [6, 7]. RANKL is a membranebound protein of TNF ...
    • ...Synovial tissues obtained at the time of total knee arthroplasty in patients who fulWlled the American College of Rheumatology Criteria for osteoarthritis and RA [11], as previously described [4]...

    Hee-Jin Yunet al. Adrenomedullin inhibits MAPK pathway-dependent rheumatoid synovial fib...

    • ...Western blot analysis of homogenized samples was performed with antibody against TfR (Santa Cruz, CA), as previously described [14]...

    Sang-Il Leeet al. Molecular scintigraphic imaging using 99m Tc–transferrin is useful for...

    • ...In addition, Lee and coworkers revealed that RASF produce actively RANKL, and thus are part of the RANK/RANKL interaction system [55]...

    Anette Knedlaet al. Developments in the synovial biology field 2006

    • ...Synovial tissues obtained at the time of total knee arthroplasty in patients who fulfilled the American College of Rheumatology Criteria for RA [9], as previously described [10]...
    • ...To analyze NF-kB (p65), nuclear extract was prepared using a previously described method [10]...

    Eun-Gyeong Leeet al. Adrenomedullin Inhibits IL1β-Induced Rheumatoid Synovial Fibroblast Pr...

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