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ThePO2 in venous valve pockets: Its possible bearing on thrombogenesis

ThePO2 in venous valve pockets: Its possible bearing on thrombogenesis,10.1002/bjs.1800680308,British Journal of Surgery,J. D. Hamer,P. C. Malone,I. A

ThePO2 in venous valve pockets: Its possible bearing on thrombogenesis   (Citations: 36)
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Journal: British Journal of Surgery - BRIT J SURG , vol. 68, no. 3, pp. 166-170, 1981
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    • ...Valvular sinus stasis has been associated with hypoxia with a gradient of increasing hypoxia from the top to the bottom of the valve sinus (Hamer et al. 1981)...
    • ...The mechanism underlying the differential expression of vWF in the venous sinus is unclear but likely relates to the peculiar microenvironment of the sinus, characterized by cyclical vortical flow, stasis, and hypoxia (Hamer et al. 1981; Lurie et al. 2003)...

    W. E. Trotmanet al. The endothelial microenvironment in the venous valvular sinus: thrombo...

    • ...A number of different cell types participate in this phenotypic shift, including endothelial cells (in which NO bioavailability and thrombomodulin levels decline), vascular smooth muscle cells (which are driven to express tissue factor), and mononuclear phagocytes (MPs) (3, 4), which express both tissue factor and plasminogen activator inhibitor-1 (PAI-1), thereby simultaneously triggering formation of fibrin and retarding its degradation...

    Hui Liaoet al. Molecular regulation of the PAI-1 gene by hypoxia: contributions of Eg...

    • ...These include venous stasis, endothelial damage, local hypercoagulable state, and postoperative immobilization [62,63]...

    Farshad Abiret al. Noncardiac Vascular Complications of Coronary Bypass Procedures:A Revi...

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