Long-term experience with liver transplantation for hepatocellular carcinoma

Long-term experience with liver transplantation for hepatocellular carcinoma,10.1007/s00535-010-0302-9,Journal of Gastroenterology,Georgios Tsoulfas,T

Long-term experience with liver transplantation for hepatocellular carcinoma   (Citations: 4)
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Background  The effect of the model for end-stage liver disease (MELD) system on the post-transplant survival of patients with hepatocellular carcinoma (HCC) has not been fully elucidated. Our objective is to review the results of liver transplantation (LT) for HCC at the Massachusetts General Hospital over a period of 12 years, with special emphasis on the effect of the MELD system. Methods  A retrospective review of 73 patients who underwent liver transplantation for HCC between 1995 and 2007. Outcome measures included demographics, tumor stage at explant, patient survival, and tumor recurrence. Results  On pathologic review of the explanted liver, 12.3% of patients were classified as stage I; 42.5% as stage II, 21.9% as stage III, and 23.3% as stage IV. The overall actual survival rate was 85% at 1 year, 82% at 3 years, 73% at 5 years, and 66% at 10 years. Overall tumor recurrence was 11%. Survival rates were higher after the MELD system (5 year survival 60% before MELD vs. 85% after MELD). Recurrence decreased from 21% to 7.5%. Conclusion  We showed improved survival for HCC after LT over the last 12 years, and especially improved survival and decreased recurrence in the time since the implementation of the MELD system.
Journal: Journal of Gastroenterology - J GASTROENTEROLOGY , vol. 46, no. 2, pp. 249-256, 2011
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    • ...Studies have consistently demonstrated increased survival rates of patients with HCC since adoption of the MELD score and the Milan criteria [4, 5]. The Milan criteria state that a patient must have one lesion smaller than 5 cm in diameter or three or fewer lesions all less than 3 cm in diameter, no evidence of metastatic disease, and no vascular invasion [6]...
    • ...Approximately 20% of patients will have a recurrence of HCC after OLT, although the literature reveals a range from 6.4 to 40% [4, 5, 8]...

    Theresa R. Harringet al. Building a Comprehensive Genomic Program for Hepatocellular Carcinoma

    • ...More importantly, great strides have recently been made in assessing the suitability of patients for liver transplantation and in achieving better results with this operation [8,9,11]...

    M. C. Kew. Whither hepatocellular carcinoma in sub-Saharan Africa?

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