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373 Hepatitis B surface antigigen presentation and HLA-DRB1∗ — Lessons from twin and peptide binding studies

373 Hepatitis B surface antigigen presentation and HLA-DRB1∗ — Lessons from twin and peptide binding studies,10.1016/S0168-8278(04)90373-X,Journal of

373 Hepatitis B surface antigigen presentation and HLA-DRB1∗ — Lessons from twin and peptide binding studies   (Citations: 7)
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Journal: Journal of Hepatology - J HEPATOL , vol. 40, pp. 112-112, 2004
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    • ... found in adult, thus immunologically mature, twins a strong genetic contribution to the anti-hepatitis B surface antigen (HBsAg) vaccine response and questionable genetic contribution to the anti-hepatitis A vaccine response with heritabilities of 61% (95% CI: 41–81%) and 36% (95% CI: –2–73%), respectively. Heritability was calculated based on variance within 202 twin pairs that were included in an open prospective study. All subjects were Caucasians. Model-fitting analyses were done to dissect genetic and environmental components of vaccine responses, revealing that the HLA-DRB1* alleles 01, 11 and 25 were associated with good HbsAg vaccine responses. Further studies by this group suggested that differences in the T cell recognition of peptide/MHC complexes are a critical event in T cell responsiveness to HBsAg [...

    T. G. Kimmanet al. Genetic Variation in the Response to Vaccination

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