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CEA, CYFRA21-1 and SCC in non-small cell lung cancer

CEA, CYFRA21-1 and SCC in non-small cell lung cancer,10.1016/0169-5002(95)00485-8,Lung Cancer,D. Moro,D. Villemain,J. P. Vuillez,C. Agnius Delord,C. B

CEA, CYFRA21-1 and SCC in non-small cell lung cancer   (Citations: 29)
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CEA, SCC and CYFRA 21-1 were measured in samples of serum coming from 105 ‘Non small cell lung cancer’ (NSCLC) patients. The present study has been carried out to compare these markers, to analyse their prognostic significance and to determine the best combination of tumor markers. The median value and interquartile range were: CYFRA 21-1: 2,3 ng/ml, CEA: 3,7 ng/ml, SCC: 1,2 ng/ml. CEA demonstrated higher values in adenocarcinomas (P = 0.04). SCC and CYFRA 21-1 were comparable in the different histologic groups. CYFRA 21-1 and CEA values were dependant on tumor stage. Advanced tumors (T3 and T4) demonstrated higher serum CYFRA 21-1 level (P = 0.0006). CYFRA 21-1 was higher than 3,3 ng/ml in 36% of patients. CEA was higher than 5 ng/ml in 38% of patients and SCC was higher than 2 ng/ml in 27% of patients. Patients with a high CEA and CYFRA21-1 serum level had a shorter survival than those with a normal serum level. In a Cox regression analysis four variables (TNM stage, age, CYFRA 21-1 and CEA level) were found to be significant in the prediction of survival; CYFRA 21-1 level had the lowest P value (P = 0.0002). The current study suggests the use of a combination of CEA and CYFRA 21-1 in the clinical care of NSCLC.
Journal: Lung Cancer , vol. 13, no. 2, pp. 169-176, 1995
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    • ...In patients with squamous cell lung cancer (SQLC), SCC levels were related to tumor stage, with levels being highest in patients with metastases [6, 7]. On the other hand, sensitivity of SCC for detection of lung cancer seems to be very low in nonsquamous cell lung cancer (NSQLC) patients [6, 7]; however, many clinicians evaluate this tumor marker in the clinical management of NSQLC patients [8, 9]. Despite this well-known limitation, SCC ...
    • ...In patients with squamous cell lung cancer (SQLC), SCC levels were related to tumor stage, with levels being highest in patients with metastases [6, 7]. On the other hand, sensitivity of SCC for detection of lung cancer seems to be very low in nonsquamous cell lung cancer (NSQLC) patients [6, 7]; however, many clinicians evaluate this tumor marker in the clinical management of NSQLC patients [8, 9]. Despite this well-known limitation, SCC ...

    Katsunori Kagohashiet al. Squamous Cell Carcinoma Antigen in Lung Cancer and Nonmalignant Respir...

    • ...By analysing the different prognostic studies (Ebert et al, 1993, 1997; Pujol et al, 1993a, 1996, 2001a; Giovanella et al, 1995; Moro et al, 1995; Paesmans et al, 1995a; Wieskopf et al, 1995; Szturmowicz et al, 1996; Brechot et al, 1997; Hamzaoui et al, 1997; Takei et al, 1997; Hirashima et al, 1998; Niklinski et al, 1998; Nisman et al, 1998, 1999; Foa et al, 1999; Kashiwabara et al, 2000; Buccheri et al, 2003), one can observe that there ...
    • ...Hosp. 4 105 37 IRMA Moro et al (1995) Warsaw Acad...

    J-L Pujolet al. CYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: ...

    • ...Whereas Moro et al. (13 ) concluded that SCC-Ag had no prognostic value, Sanchez de Cos et al. (18 ) found it to be a predictor of survival...

    Jan Kulpaet al. Carcinoembryonic Antigen, Squamous Cell Carcinoma Antigen, CYFRA 21-1,...

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