Somatostatin Analogues and Pancreatic Fistulas

Somatostatin Analogues and Pancreatic Fistulas,10.1159/000201409,Digestion,C. Bassi,M. Falconi,E. Caldiron,A. Bonora,R. Salvia,P. Pederzoli

Somatostatin Analogues and Pancreatic Fistulas   (Citations: 8)
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Consideration is given to the characterisation of pancreatic fistulas (PFs), the rationale for their treatment, and supportive and specific treatment measures. Choice of treatment should be based not only on the percentage of closures achieved, but also on their time and cost. The combined use of parenteral nutrition (TPN) and somatostatin inhibits pancreatic secretion well; no therapy can inhibit it completely. Presumptive use of octreotide, a subcutaneous formulation of somatostatin, in patients undergoing elective pancreatic surgery, reduced postoperative complications, mainly PFs, in about 500 patients in two controlled double-blind clinical studies, confirming the use of octreotide both in prophylaxis and treatment. Octreotide has been tested on outpatients after a brief hospitalisation period, at a dose of 100 mg three times a day. Home treatment does not involve co-administration of TPN, thus lowering not only costs but also risks. Optimal doses and the types of fistula amenable to this therapy need to be established and we only use out-patient treatment for chronic low-output fistulas.Copyright © 1996 S. Karger AG, Basel
Journal: Digestion , vol. 57, no. 1, pp. 94-96, 1996
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    • ...The treatment requires lengthy admission and is costly [11, 12]...

    Jorma Halttunenet al. Treatment of Pancreatic Fistulas

    • ...There are a variety of approaches available for the therapy of pancreatic fistulas, including conservative treatments with prolonged pancreatic rest (no oral intake with total parenteral nutrition and octreotide administration) and surgery [2, 11, 12]...

    J. Halttunenet al. The endoscopic management of pancreatic fistulas

    • ...Standard management includes total parenteral nutrition, somatostatin analogues, and, more recently, endoscopic stent placement in the pancreatic duct [63, 64, 65, 66, 67, 68] or percutaneous radiological catheterization of the main pancreatic duct [69], with the aim of aiding the physiological deflux of the pancreatic juice...

    Carlo Procacciet al. [Without Title]

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