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Molecular Mechanisms Related to Parturition-Induced Stress Urinary Incontinence

Molecular Mechanisms Related to Parturition-Induced Stress Urinary Incontinence,10.1016/j.eururo.2008.02.027,European Urology,Guiting Lin,Alan W. Shin

Molecular Mechanisms Related to Parturition-Induced Stress Urinary Incontinence   (Citations: 5)
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BackgroundThe molecular mechanisms underlying stress urinary incontinence (SUI) at the tissue level are poorly understood.
Journal: European Urology - EUR UROL , vol. 55, no. 5, pp. 1213-1223, 2009
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    • ...The sneeze test was introduced by Lin et al. in 1998 for use in rats to test for decreased urethral resistance to leakage and presumptive SUI (Lin et al. 1998)...
    • ...To perform this test, chili powder or a clipped whisker is placed in the rat’s nose, inducing sneezing (Lin et al. 1998)...
    • ...No leakage was induced in uninjured rats (Lin et al. 1998)...
    • ...Animal models for SUI in rodents were first introduced by performing vaginal distension (VD) to simulate the maternal injuries of childbirth in female rats (Lin et al. 1998; Sievert et al. 2001)...
    • ...The VD model has became the most used model to study mechanisms of injury and tissue recovery in response to childbirth, since it was introduced over 10 years ago (Lin et al. 1998)...
    • ...Urethral resistance is significantly decreased after VD as confirmed by sneeze testing, LPP testing, and urethral closure pressure testing (Lin et al. 1998; Kamo et al. 2006; Pan et al. 2007)...
    • ...Lin et al. initially used a 12Fr Foley catheter inflated with 2.0 ml in virgin rats and 2.5 ml in retired breeder rats for 4 h (Lin et al. 1998)...
    • ...Marked cellular swelling and edema in the levator muscles has been shown 1 day after VD (Lin et al. 1998)...
    • ...Smooth muscle between the vagina and the urethra in incontinent rats was also disrupted and thinned (Lin et al. 1998)...

    Hai-Hong Jianget al. Animal Models of Stress Urinary Incontinence

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