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Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats,10.1097/HJH.0b013e32832c419a,Journal of

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats   (Citations: 3)
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Qi Guo, Takefumi Mori, Yue Jiang, Chunyan Hu, Yusuke Osaki, Yoshimi Yoneki, Ying Sun, Takuma Hosoya, Akihiro Kawamata, Susumu Ogawa, Masaaki Nakayama, Toshio Miyatahttp://academic.research.microsoft.com/io.ashx?type=5&id=33193980&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: Journal of Hypertension - J HYPERTENSION , vol. 27, no. 8, pp. 1664-1671, 2009
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    • ...Although an 8% salt diet does not significantly influence blood pressure in SD rats, when 1% MGO, a dose that does not influence blood pressure, was added to drinking water, it increased blood pressure [44]...
    • ...One percent MGO in drinking water was used because this was the dose that increased plasma level of MGO (approximately ten times) and was equivalent to those of CKD stage 5. Since an increase in oxidative stress in the renal medulla causes a reduction of MBF and salt sensitivity of hypertension, as described above, carbonyl stress could interact with oxidative stress and participate in the salt sensitivity of hypertension [44]...
    • ...Sprague Dawley rats were given 1% MGO in drinking water and insulin sensitivity was determined by glucose clamp technique [44]...

    Takefumi Moriet al. Oxidative/Carbonyl Stress in the Renal Circulation and Cardiovascular ...

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