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Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model

Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model,10.1016/S1344-6223(02)00

Expression of cytokines, neurotrophins, neurotrophin receptors and NOS mRNA in dorsal root ganglion of a rat tourniquet model   (Citations: 7)
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We studied temporal changes in mRNA expression patterns for nitric oxide synthase (NOS), cytokines, neurotrophins and neurotrophin receptors in the dorsal root ganglion (DRG) of the rat, after application of a tourniquet to the hind limb. Collapsed myelin and degenerated axons were observed in the tourniquet segment of the sciatic nerve. Gene expression level of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) was significantly increased in ipsilateral DRG samples at 4h after application of the tourniquet but not in the contralateral or control DRG samples. Upregulation of tumor necrosis factor (TNF)-α, activating transcription factor (ATF)-3 and neurotrophin-3 (NT3) expressions began at 1h after application of the tourniquet in ipsilateral DRGs. It is likely that transient expression of these molecules triggers secondary events that may be beneficial to wound repair and regeneration.
Journal: Legal Medicine - LEG MED , vol. 5, pp. S271-S274, 2003
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    • ...All the agents that we noted had caused dying back axonal degeneration in our cultures, including gpl20, ddC and acrylamide, increased neuronal intracellular NO production (Fig 11-3 A). This observation correlates with previous studies showing that neuronal nitric oxide synthase (nNOS) gene expression is significantly increased at 4 hours in ipsilateral DRG samples following sciatic nerve injury in a rat tourniquet model (Mizusawa et al., ...

    Sanjay C. Keswaniet al. An Endogenous Pathway Preventing Axonal Degeneration Mediated by Schwa...

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