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Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction

Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction,10.1161/CIRCULATIONAHA.106.644682,Circulation,M.

Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction   (Citations: 84)
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Journal: Circulation , vol. 114, no. 21, pp. 2232-2239, 2006
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    • ...Anterior mitral leaflet (AML) systolic anterior motion (SAM) is classically demonstrated in 70% of hypertrophic cardiomyopathy (HCM) patients at rest or with exercise [15]...

    Anand Chockalingamet al. Echocardiography in stress cardiomyopathy and acute LVOT obstruction

    • ...In a prospective study by Maron et al. 37% of patients showed an obstruction of the left ventricular outflow tract at rest producing an intraventricular pressure gradient which exceeds 50 mmHg [21]...
    • ...Therefore about 70% of HCM patients developed dynamic LV outflow tract obstruction (gradients >30 mmHg) during stress echocardiography [21]...
    • ...During stress echocardiography up to 70% of patients show LVOT obstruction (at rest: 37%) [21]...

    Jörg Lauschkeet al. Athlete’s heart or hypertrophic cardiomyopathy?

    • ...Obstruction to LV outflow (gradient, ≥30 mmHg at rest) produces increased intraventricular pressures and wall stress [10, 11] and is a strong determinant of progressive heart failure and cardiovascular death...
    • ...Finally, outflow gradients are particularly common, occurring in 70% of HCM patients at rest or with physiologic exercise [11]...

    Barry J. Maron. Sudden Death in Hypertrophic Cardiomyopathy

    • ...In an additional proportion of patients, close to 40%, a gradient ≥50 mmHg can be elicited with exercise [63]...
    • ...[63]. Any gradient ≥30 mmHg in resting conditions is considered to reflect a clinically relevant degree of obstruction in HCM patients; however, in the presence of complete SAM producing prolonged systolic septal contact, peak gradients may well exceed 150 mmHg at rest [61, 62]...

    Iacopo Olivottoet al. The Many Faces of Hypertrophic Cardiomyopathy: From Developmental Biol...

    • ...LVoutflow obstruction, observed in more than two thirds of HCM patients [31], the pathological increase in intracavitary pressures may substantially contribute to myocar-...

    Franco Cecchiet al. Microvascular Dysfunction, Myocardial Ischemia, and Progression to Hea...

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