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The T-786->C Mutation in Endothelial Nitric Oxide Synthase Is Associated With Hypertension

The T-786->C Mutation in Endothelial Nitric Oxide Synthase Is Associated With Hypertension,10.1161/01.HYP.0000013703.07316.7F,Hypertension,M. E. Hyndm

The T-786->C Mutation in Endothelial Nitric Oxide Synthase Is Associated With Hypertension   (Citations: 35)
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Journal: Hypertension , vol. 39, no. 4, pp. 919-922, 2002
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    • ...Recently, with the completion of the human genome project, the importance of genes as causes of diseases or as predisposing factors has become indisputable [4-8]...

    Rozalia Dimitriouet al. Genetic predisposition to fracture non-union: a case control study of ...

    • ... 66 (64)* na 36 51 (54) 111 (55) 40 (43) 78 (38) 2 (2) 12 (5) 142 (76) 300 (74) 44 (23) 102 (25) 0.06 37 325 (52) 536 (55) 250 (40) 368 (38) 42 (6) 56 (5) 900 (72) 1440 (75) 334 (27) 480 (25) 0.51 1, white 48 (42) 53 (46) 54 (48) 53 (46) 10 (8) 7 (6) 150 (66) 159 (70) 74 (33) 67 (29) 0.36 1, black 57 (62) 45 (51) 31 (34) 36 (41) 3 (3) 6 (6) 145 (79) 126 (72) 37 (20) 48 (27) 0.65 Total 4633 (62) 6262 (67) 2342 (31) 2593 (28) 409 (5) 397 (4) ...
    • ... 309 (82) 33 (20) 67 (18) 0.36 47 90 (82) 578 (80) 20 (18)* 144 (20)* na 43 184 (72) 100 (71) 62 (24) 38 (27) 9 (3) 2 (1) 430 (84) 238 (85) 80 (15) 42 (15) 0.20 35 69 (63) 66 (78) 40 (36)* 18 (21)* na 36 59 (63) 132 (65) 33 (35) 65 (32) 1 (1) 4 (1) 151 (81) 329 (81) 35 (18) 73 (18) 0.12 48 97 (75) 105 (81) 31 (24) 22 (17) 1 (1) 2 (2) 0.38 49 158 (81) 151 (83) 37 (19) 27 (15) 0 4 (2) 0.14 1, white 78 (70) 86 (81) 30 (27) 14 (13) 3 (2) 5 (4) ...
    • ... 62 (24) 38 (27) 9 (3) 2 (1) 430 (84) 238 (85) 80 (15) 42 (15) 0.20 35 69 (63) 66 (78) 40 (36)* 18 (21)* na 36 59 (63) 132 (65) 33 (35) 65 (32) 1 (1) 4 (1) 151 (81) 329 (81) 35 (18) 73 (18) 0.12 48 97 (75) 105 (81) 31 (24) 22 (17) 1 (1) 2 (2) 0.38 49 158 (81) 151 (83) 37 (19) 27 (15) 0 4 (2) 0.14 1, white 78 (70) 86 (81) 30 (27) 14 (13) 3 (2) 5 (4) 186 (83) 186 (88) 36 (16) 24 (11) 0.98 1, black 56 (62) 57 (67) 29 (32) 24 (28) 5 (5) 4 (4) ...
    • ... (10) 524 (10) 0.43 4 34 (32) 240 (40) 48 (45) 277 (46) 24 (22) 82 (13) 116 (54) 757 (63) 96 (45) 441 (36) 0.89 51 38 (27) 16 (33) 69 (50) 22 (45) 30 (21) 10 (20) 145 (52) 54 (56) 129 (47) 42 (43) 0.65 32 26 (24) 27 (28) 50 (47) 46 (48) 29 (27) 21 (22) 102 (48) 100 (53) 108 (51) 88 (46) 0.88 1, white 37 (33) 36 (31) 62 (55) 61 (53) 13 (11) 16 (14) 136 (60) 133 (58) 88 (39) 93 (41) 0.22 1, black 49 (54) 41 (47) 36 (40) 41 (47) 5 (5) 4 (4) ...
    • ... (45) 441 (36) 0.89 51 38 (27) 16 (33) 69 (50) 22 (45) 30 (21) 10 (20) 145 (52) 54 (56) 129 (47) 42 (43) 0.65 32 26 (24) 27 (28) 50 (47) 46 (48) 29 (27) 21 (22) 102 (48) 100 (53) 108 (51) 88 (46) 0.88 1, white 37 (33) 36 (31) 62 (55) 61 (53) 13 (11) 16 (14) 136 (60) 133 (58) 88 (39) 93 (41) 0.22 1, black 49 (54) 41 (47) 36 (40) 41 (47) 5 (5) 4 (4) 134 (74) 123 (71) 46 (25) 49 (28) 0.16 Total 1723 (69) 2745 (70) 653 (26) 1003 (25) 114 (4) ...
    • ... (36) 0.89 51 38 (27) 16 (33) 69 (50) 22 (45) 30 (21) 10 (20) 145 (52) 54 (56) 129 (47) 42 (43) 0.65 32 26 (24) 27 (28) 50 (47) 46 (48) 29 (27) 21 (22) 102 (48) 100 (53) 108 (51) 88 (46) 0.88 1, white 37 (33) 36 (31) 62 (55) 61 (53) 13 (11) 16 (14) 136 (60) 133 (58) 88 (39) 93 (41) 0.22 1, black 49 (54) 41 (47) 36 (40) 41 (47) 5 (5) 4 (4) 134 (74) 123 (71) 46 (25) 49 (28) 0.16 Total 1723 (69) 2745 (70) 653 (26) 1003 (25) 114 (4) 164 (4) ...

    Elias Zintzaraset al. Endothelial NO Synthase Gene Polymorphisms and Hypertension

    • ...The NOS3 -786 T/C polymorphism is associated with coronary vasospasm (Nakayama et al. 1999) and myocardial infarction in Japanese patients (Nakayama et al. 2000), with increased risk of essential hypertension in Caucasians (Hyndman et al. 2002), and with decreased cardiac function in African Americans (McNamara et al. 2009)...

    Félix Gómez-Gallegoet al. The −786 T/C polymorphism of the NOS3 gene is associated with elite pe...

    • ...Moreover, -786C NOS3 allele has been related with impaired activity of the eNOS enzyme, coronary spasm, and impaired endothelium-dependent vasodilatation in CAD patients [17,18]...

    Ignacio Cruz-Gonzálezet al. Association between -T786C NOS3 polymorphism and resistant hypertensio...

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