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Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study

Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study,10.10

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Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study   (Citations: 16)
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Journal: Gastrointestinal Endoscopy - GASTROINTEST ENDOSCOP , vol. 66, no. 4, pp. 798-803, 2007
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    • ...Although some studies reported the effect of a stent covered with an antitumor drug-releasing membrane, drug-eluting uncovered stent coated with an antitumor drug deposited the stent surface with or without polymer matrix is not developed in the gastrointestinal tract [23, 24]...

    Jong Kyu Park, et al. Outcome of palliative self-expanding metal stent placement in malignan...

    • ...Additionally, future development of drug-eluting SEMS [17] may add to the palliation and treatment options offered by the biliary endoscopist...

    Harry R. AslanianPriya, et al. Ongoing Challenges in the Endoscopic Management of Hilar Cholangiocarc...

    • ...These stents were reported to be safe and effective in animal and human studies [...

    Guido Costamagna, et al. Update in Biliary Endoscopy

    • ...Recently, however, an animal experiment [13] and a human pilot study [14] on the use of DES in bile ducts have been reported, and a comparative study between the use of conventional non-drug-coated stents and DES is in progress...
    • ...In contrast to vascular DES, in non-vascular DES it is important that drugs permeate the large contact area between the stent and the tumor mass; therefore, the drug is incorporated into the coating membrane of the stent metal mesh [3, 5, 13, 14, 17]...
    • ...To expand upon our animal experiments and evaluate the safety and efficacy of MSCPM treatment, we conducted a pilot study in 21 human patients diagnosed with unresectable malignant biliary obstructions [14]...

    Dong Ki Lee. Drug-eluting stent in malignant biliary obstruction

    • ...In a further advance on this, covered stents with linings bounded to cytotoxic agents, such as paclitaxel, are also now available for clinical use, although there are no significant data regarding their efficacy in humans [60]...

    G. Garcea, et al. Palliation of Malignant Obstructive Jaundice

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