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Mechanisms of Actions of Inhaled Anesthetics

Mechanisms of Actions of Inhaled Anesthetics,Alastair J. J. Wood,Jason A. Campagna,Keith W. Miller,D. Phil,Stuart A. Forman

Mechanisms of Actions of Inhaled Anesthetics   (Citations: 79)
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Published in 2010.
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    • ...receptor/ion channel, for example, is thought by many investigators to be an important anesthetic target ...

    Wendy A. Leaet al. A High-Throughput Approach for Identification of Novel General Anesthe...

    • ...The mechanism of action of volatile general anesthetics still remains an enigma in medical science and biology (1-4)...
    • ...Volatile general anesthetics can act on all proteins in vivo (1-3, 9). Consequently, it is necessary to differentiate the diversified effects of anesthesia induction...
    • ...The first approach is based on the hypothesis that different volatile general anesthetics act on different in vivo protein targets (1-4, 9). The second approach views volatile general anesthetics as all acting on the same protein target and all other effects are independent of anesthesia depth...
    • ...For the first hypothesis, different volatile general anesthetics have been shown to have different profiles on the activity of ion channels, the NMDA receptor, the GABA receptor, and a number of other proteins (1-8)...

    Aili Wanget al. In vivo measurement of protein functional changes

    • ... Although over the years a large number of different ion channels, receptors, enzymes and other proteins have been investigated as putative anaesthetic target...

    Nicholas P. Franks. General anaesthesia: from molecular targets to neuronal pathways of sl...

    • ...(1) fragment the continuous EEG signal (dotted line in the lower diagram of Fig. 1), into a sequence of motifs (some examples are shown in grey); (2) identify each motif as belonging to one of the six possible types (as shown in the middle row of diagrams in Fig. 1)—according to their shape [we describe the six types as two varieties each of ‘slopes’ (motifs #2 and #5 in Fig. 1), ‘peaks’ (motifs #1 and #6), and ‘troughs’ (motifs #3 and ...

    E. Olofsenet al. Permutation entropy of the electroencephalogram: a measure of anaesthe...

    • ...However, the in vivo effects induced by Fa131 were distant from the deep central depressant activity exerted by these agents (Campagna et al., 2003; Herd et al., 2007), presumably because of its higher efficacy for a2-containing receptors...

    Sebastian P. Fernandezet al. Flavan3-ol derivatives are positive modulators of GABA A receptors wit...

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