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Tamoxifen and contralateral breast cancer inBRCA1 andBRCA2 carriers: An update

Tamoxifen and contralateral breast cancer inBRCA1 andBRCA2 carriers: An update,10.1002/ijc.21536,International Journal of Cancer,Jacek Gronwald,Nadine

Tamoxifen and contralateral breast cancer inBRCA1 andBRCA2 carriers: An update   (Citations: 47)
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Jacek Gronwald, Nadine Tung, William D. Foulkes, Kenneth Offit, Ruth Gershoni, Mary Daly, Charmaine Kim-Sing, Hakan Olsson, Peter Ainsworth, Andrea Eisen, Howard Saal, Eitan Friedmanhttp://academic.research.microsoft.com/io.ashx?type=5&id=33804773&selfId1=0&selfId2=0&maxNumber=12&query=
Journal: International Journal of Cancer - INT J CANCER , vol. 118, no. 9, pp. 2281-2284, 2006
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    • ..., provide a reasonable hypothesis; the G-allele of the MDM2 SNP309 locus could contribute to the increased cancer risk observed in female p53 mutation carriers through the preferential estrogen-dependent stimulation of transcription of the MDM2 gene. If true, this model predicts that estrogen reduction or withdrawal from G-allele MDM2 SNP309 patients could be incorporated in prevention strategies for p53-germlinc carriers, for whom cancer prevention strategies are limited, much as they have been successfully implemented for BRCA-mutation carriers ...

    Gurinder Singh Atwalet al. An Information-Theoretic Analysis of Genetics, Gender and Age in Cance...

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