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Mice lacking 3 integrins are osteosclerotic because of dysfunctional osteoclasts
Mice lacking 3 integrins are osteosclerotic because of dysfunctional osteoclasts,K. P. Mchugh,K. Hodivala-dilke,M. H. Zheng,N. Namba,J. Lam,D. Novack,
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Mice lacking 3 integrins are osteosclerotic because of dysfunctional osteoclasts
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Citations: 187
)
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K. P. Mchugh
,
K. Hodivala-dilke
,
M. H. Zheng
,
N. Namba
,
J. Lam
,
D. Novack
,
X. Feng
,
F. P. Ross
,
R. O. Hynes
,
S. L. Teitelbaum
Published in 2000.
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Citation Context
(40)
...,
...
Yongzheng He
,
et al.
Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorpti...
... Consequently, they failed to attach to the bone surface
...
Gregory R. Mundy
,
et al.
Advances in osteoclast biology: old findings and new insights from mou...
... The key role of α
V
β
3
has been demonstrated in a β
3
knockout mouse that has a high BMD phenotype due to impaired osteoclast function
...
E. Michael Lewiecki
.
New targets for intervention in the treatment of postmenopausal osteop...
...In our recent studies we have found that β3 integrin is expressed relatively late in the sequence of osteoclast differentiation, after the induction of osteoclast-associated genes such as tartrate-resistant acid phosphatase (TRAP) and cathepsin K. This would suggest that the initial attachement of the osteoclast precursor does not involve the β3 integrin, but is mediated via alternate attachment receptors. In support of this speculation, the β3 integrin is not essential for preosteoclast attachment, since, as we previously reported, the β3 knockout mouse expresses normal or even slightly increased numbers of osteoclasts on the bone surfaces.
...
K P McHugh
,
et al.
The role of cell–substrate interaction in regulating osteoclast activa...
...,
...
Chang Yang
,
et al.
NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced ...
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Citations
(187)
Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity
Yongzheng He
,
Karl Staser
,
Steven D. Rhodes
,
Yaling Liu
,
Xiaohua Wu
,
Su-Jung Park
,
Jin Yuan
,
Xianlin Yang
,
Xiaohong Li
,
Li Jiang
,
Shi Chen
,
Feng-Chun Yang
Journal:
PLOS One
, vol. 6, no. 9, 2011
Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury
Maria S. Moreira
,
Irineu T. Velasco
,
Leila S. Ferreira
,
Suely K. K. Ariga
,
Fatima Abatepaulo
,
Lea Tenenholz Grinberg
,
Márcia M. Marques
Journal:
Journal of Photochemistry and Photobiology B-biology - J PHOTOCHEM PHOTOBIOL B-BIOL
, vol. 105, no. 3, pp. 207-215, 2011
Breast cancer at bone metastatic sites: recent discoveries and treatment targets
Osama Hussein
,
Svetlana V. Komarova
Journal:
Journal of Cell Communication and Signaling
, vol. 5, no. 2, pp. 85-99, 2011
Advances in osteoclast biology: old findings and new insights from mouse models
Gregory R. Mundy
,
James R. Edwards
Journal:
Nature Reviews Rheumatology - NAT REV RHEUMATOL
, vol. 7, no. 4, pp. 235-243, 2011
New targets for intervention in the treatment of postmenopausal osteoporosis
E. Michael Lewiecki
Journal:
Nature Reviews Rheumatology - NAT REV RHEUMATOL
, vol. 7, no. 11, pp. 631-638, 2011