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Gastric and intestinal claudin expression at the invasive front of gastric carcinoma

Gastric and intestinal claudin expression at the invasive front of gastric carcinoma,10.1111/j.1349-7006.2007.00490.x,Cancer Science,Yoshiko Matsuda,S

Gastric and intestinal claudin expression at the invasive front of gastric carcinoma   (Citations: 21)
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Journal: Cancer Science - CANCER SCI , vol. 98, no. 7, pp. 1014-1019, 2007
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    • ...These findings demonstrate that tricellulin is a key mediator for this epithelial barrier mechanism at the tricellular contacts.Evidence has accumulated indicating abnormal expression of TJs in various human malignancies. A loss of claudin expression at the invasive front of advanced gastric carcinomas (GCs) results in higher malignancy grades with regard to potential metastatic ability and patient outcomes [...

    Risayo Masudaet al. Negative Regulation of the Tight Junction Protein Tricellulin by Snail...

    • ...Matsuda et al [15] have recently proposed a gastric cancer classification based on claudin expression where the intestinal-type overexpresses claudins 3 and 4 whereas the gastric-type overexpresses claudin-18...

    Erika Rendón-Huertaet al. Distribution and Expression Pattern of Claudins 6, 7, and 9 in Diffuse...

    • ...Japanese paper showed similar result, decreased CLDN 3 expression in normal gastric mucosa [34]...

    Dorottya Nagy Szakálet al. Mucosal expression of claudins 2, 3 and 4 in proximal and distal part ...

    • ...In normal gastric mucosa, positive immunostaining has been detected for claudin-18, but not for claudin-4 [5]...
    • ...Moreover, claudin-4 is reportedly highly expressed in gastric intestinal-type adenocarcinoma [5, 8, 9]. To date, several studies have been reported regarding the biological functions of claudin-4 in gastric cancer...
    • ...As previously reported, it is probably true that claudin-4 expression is decreased in diffuse-type adenocarcinoma [5, 7, 8, 12]...
    • ...In immunohistochemistry, as previously reported [5, 8, 12], the staining patterns for claudin-4 and ZO-1 in carcinoma, metaplastic epithelia, and normal mucosa were membranous, and nucleus and cytoplasm were faintly stained...
    • ...Therefore, disruption of the tight junction can cause the loss of cell polarity, resulting in an abnormal infl ux of growth factors, which could provide autocrine and paracrine stimulation to tumorigenic epithelial cells [5]...
    • ...In gastric cancer, this result was confi rmed by the result that a signifi cant correlation was seen between the expression of claudin-4 estimated by immunohistochemistry and the expression of claudin-4 mRNA (P = 0.0030; Fig. 3). Claudin-4 is reportedly highly expressed in metaplastic epithelium and carcinoma, but little expressed in normal epithelium [5, 8, 9]. These results may be related to the fact that intestinal-type adenocarcinomas ...
    • ...Claudin-4 is reportedly highly expressed in gastric intestinal-type adenocarcinoma [5, 7, 8, 12], and the expression of occludin and ZO-1 is reduced in poorly differentiated adenocarcinoma [14]...

    Satoshi Ohtaniet al. Expression of tight-junction-associated proteins in human gastric canc...

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