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Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction

Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction,10.1016/j.cardfail.2010.02.004,Journal of Cardiac Failure

Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction  
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BackgroundApelin is a novel endogenous peptide with inotropic and vasodilatory properties that is the ligand for the APJ receptor. Apelin and APJ are widely distributed in the vasculature of a number of organs and peripheral venous apelin is reduced in heart failure (HF). The location of apelin production in humans with and without HF was investigated.
Journal: Journal of Cardiac Failure - J CARD FAIL , vol. 16, no. 7, pp. 556-561, 2010
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