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Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis

Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis,10.1002/ajmg.1320370755,American Journal

Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis   (Citations: 84)
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Journal: American Journal of Medical Genetics - AMER J MED GENET , vol. 37, no. S7, pp. 274-281, 2005
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    • ...Some authors report that seizures in DS could be associated with medical complications such as cardiovascular abnormalities, recurrent infections or nutritional deficiencies [56-60]...

    Giovanni Sorgeet al. Epilepsy and chromosomal abnormalities

    • ...From autopsy studies (Becker et al. 1986; Scott et al. 1983; Wisniewski 1990), magnetic resonance imaging studies (Aylward et al. 1997; Kesslak et al. 1994; Pinter et al. 2001), and mouse models of DS (Baxter et al. 2000; Roper et al. 2006), DS has been related to decreased brain weight and size, disproportionately smaller cerebellar volumes, decreased cortical sulcation, a reduced number and density of neurons, and reduced synaptic ...

    Jianhua Wuet al. Strategy adoption and locomotor adjustment in obstacle clearance of ne...

    • ...Developing trisomic humans and mice have been described as ‘‘developmentally delayed’’ (Holtzman et al. 1996; Reeves et al. 1995; Wisniewski 1990)...

    Clara S. Mooreet al. The power of comparative and developmental studies for mouse models of...

    • ...Studies of the brain in DS have shown that individuals with trisomy have smaller brains overall [Crome et al., 1966; Crome and Stern, 1972; Schapiro et al., 1987; Wisniewski, 1990; Weis et al., 1991; Raz et al., 1995; Pearlson et al., 1998; Pinter et al., 2001]...
    • ...This reduction is accompanied by regional shape changes that include an anteroposteriorly shorter cerebrum [Wisniewski, 1990], reduced frontal lobes [Benda, 1971; Crome and Stern, 1972; Wisniewski, 1990], and compressed occipital lobes that are steeply sloped in height [Kemper, 1988]...
    • ...This reduction is accompanied by regional shape changes that include an anteroposteriorly shorter cerebrum [Wisniewski, 1990], reduced frontal lobes [Benda, 1971; Crome and Stern, 1972; Wisniewski, 1990], and compressed occipital lobes that are steeply sloped in height [Kemper, 1988]...
    • ...Following Crome et al. [1966], numerous studies have reported reduced volume of the cerebellum in humans with DS [Crome et al., 1966; Benda, 1971; Crome and Stern, 1972; Ieshima et al., 1984; Wisniewski, 1990; Weis et al., 1991; Raz et al., 1995; Aylward et al., 1997; Pinter et al., 2001; Kaufmann et al., 2003; White et al., 2003], as well as underdeveloped cerebellar folia [Benda, 1971]...

    Kristina Aldridgeet al. Differential effects of trisomy on brain shape and volume in related a...

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