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Deregulation of cofactor of BRCA1 expression in breast cancer cells

Deregulation of cofactor of BRCA1 expression in breast cancer cells,10.1002/jcb.21568,Journal of Cellular Biochemistry,Jianlong Sun,Gareth Watkins,Ash

Deregulation of cofactor of BRCA1 expression in breast cancer cells   (Citations: 7)
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Journal: Journal of Cellular Biochemistry - J CELL BIOCHEM , vol. 103, no. 6, pp. 1798-1807, 2008
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    • ... A full recovery was not necessarily expected, as previous experiments have failed to completely recover the NELF complex, likely because NELF subunits are mutually regulate...

    Ramendra N Sahaet al. Rapid activity-induced transcription of Arc and other IEGs relies on p...

    • ... In humans, low expression levels of NELF-B (also known as COBRA1, Co-factor of BRCA1) are associated with metastatic breast cancer ...

    Xiaoling Wanget al. NELF Potentiates Gene Transcription in the Drosophila Embryo

    • ...In addition, COBRA1 expression was inversely correlated with breast cancer progression, with low expression in primary tumors from those patients who had distant metastasis and local recurrence [29]...
    • ...Combined with the finding that reduced COBRA1 expression is associated with metastatic and recurrent breast cancer [29], the effect of COBRA1 knockdown on gene expression lends further support to the notion that COBRA1 plays an important role in suppressing breast cancer development...
    • ...These clinical features of BRCA1-associated tumors are reminiscent of the association of low COBRA1 expression with metastatic breast cancer [29]...

    Sarah E. Aiyaret al. Concerted Transcriptional Regulation by BRCA1 and COBRA1 in Breast Can...

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