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A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease

A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease,10.1002/

A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease   (Citations: 56)
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Journal: Journal of Neuroscience Research - J NEUROSCI RES , vol. 59, no. 4, pp. 528-533, 2000
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    • ...Syn 208 is mouse monoclonal antibody that was raised against full-length recombinant human -syn and recognizes an epitope between amino acid residues 89–110 in human -syn [19, 53]...
    • ...SNL-4 is a rabbit polyclonal antibody raised against a synthetic peptide corresponding to residues 2–12 in human -syn [19]...
    • ...Syn211 is a mouse monoclonal antibody speciWc for human -syn, requiring amino acids 121–125 [19]...
    • ...Analysis with antibody Syn211, which recognizes an epitope in the C-terminus of -syn [19], was used to demonstrate similar immunoreactivity for all proteins...
    • ...All three antibodies, Syn 505, Syn 506 and Syn 514, have N-terminal epitopes that minimally require amino acids residues 2–4 in -syn; however, the sequence recognized may extend further up to residue 12 (Fig. 2). The selectivity of these antibodies to detect aggregated -syn cannot be solely due to their reactivity to the N-terminus, since SNL-4, an antibody that also reacts with the extreme N-terminus, does not share this selectivity [19]...

    Elisa A. Waxmanet al. Characterization of antibodies that selectively detect α-synuclein in ...

    • ... For instance, nitration of tyrosine residues within the α-synuclein protein is found to accumulate in the Lewy bodies that are associated with PD and other synucleopathie...

    Julie K Andersen. Oxidative stress in neurodegeneration: cause or consequence?

    • ...Several reports of oxidative (nitration) damage to α-synuclein in synucleopathies have been published (Duda et al., 2000; Giasson et al., 2000) as well as following MPTP administration (Przedborski et al., 2001)...

    Julie K. Andersen. Paraquat and iron exposure as possible synergistic environmental risk ...

    • ...Immunohistochemistry was performed using antibodies to phosphorylated tau (PHF-1, 17026) and AS (LB509, syn303) [3, 7, 12, 10, 16, 20]...
    • ...Antibodies to AS detect LBs and Lewy neurites with greater sensitivity and specificity than any other previously reported molecular probes [3, 10]...

    Alexander R. Judkinset al. Co-occurrence of Parkinson's disease with progressive supranuclear pal...

    • ...There is also evidence that a-synuclein may associate with synaptic vesicles because a-synuclein has been detected in vesicular fractions of human brain (Irizarry et al., 1996) and binds to both synthetic membranes (Davidson et al., 1998) and vesicles isolated from rat brain (Jensen et al., 1998)...
    • ...a-Synuclein has been shown to bind to artificial phospholipid membranes (Davidson et al., 1998) as well as to synaptic vesicles (Jensen et al., 1998), which would support a vesicleanchoring function...

    Diane D. Murphyet al. Synucleins Are Developmentally Expressed, and a-Synuclein Regulates th...

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