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A toxicokinetic study to elucidate 3-hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rats

A toxicokinetic study to elucidate 3-hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rat

A toxicokinetic study to elucidate 3-hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rats   (Citations: 2)
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    • ...Urinary 3-hydroxy-benzo[a]pyrene (3-OHBaP), a metabolite of benzo[a]pyrene (BaP), has been increasingly adopted as a biomarker for assessing BaP exposure (Marie et al. 2010; Leroyer et al. 2010; Payan et al. 2009; Förster et al. 2008; Buratti et al. 2007; Lafontaine et al. 2006; Gendre et al. 2004; Bouchard and Viau 1996), despite urinary 1-hydroxpyrene (1-OHP) remains the most common surrogate in assessing human exposure to BaP and ...
    • ...Similarly, »0.07 and 0.21% of the administered dose were excreted as urinary 3-OHBaP, 24 and 72 h, respectively, after intravenous injection of 40 mol/kg of 3-OHBaP in rats (Marie et al. 2010)...
    • ...Animal studies have established that 0.07–0.21% of injected BaP dose can be collected in urine as 3-OHBaP (Marie et al. 2010; Payan et al. 2009); however, corresponding knowledge of metabolic characteristics for humans is lacking...

    Yeh-Chung Chienet al. Excretion kinetics of urinary 3-hydroxybenzo[a]pyrene following dietar...

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