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Mixing behavior of colyophilized binary systems

Mixing behavior of colyophilized binary systems,10.1021/JS9704801,Journal of Pharmaceutical Sciences,Sheri L. Shamblin,Lynne S. Taylor,George Zografi

Mixing behavior of colyophilized binary systems   (Citations: 42)
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Journal: Journal of Pharmaceutical Sciences - J PHARM SCI , vol. 87, no. 6, pp. 694-701, 1998
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    • ...Nifedipine PVP Misc Tg, FTIR (51) Felodipine PVP Misc Tg, FTIR (51) Ketoconazole PVP Misc Tg (63) Sucrose PVP Misc Tg, FTIR (66) Indomethacin PVP Misc Tg, FTIR (67) Sucrose Dextran Misc Tg (66) Ibuprofen Dextran Immisc Microscopy (64) Indomethacin Dextran Immisc Tg (this study) Itraconazole Eudragit E100 Partially Tg (65)...
    • ...Nifedipine PVP Misc Tg, FTIR (51) Felodipine PVP Misc Tg, FTIR (51) Ketoconazole PVP Misc Tg (63) Sucrose PVP Misc Tg, FTIR (66) Indomethacin PVP Misc Tg, FTIR (67) Sucrose Dextran Misc Tg (66) Ibuprofen Dextran Immisc Microscopy (64) Indomethacin Dextran Immisc Tg (this study) Itraconazole Eudragit E100 Partially Tg (65)...

    Patrick J. Marsacet al. Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Sol...

    • ...there is some evidence in the literature suggesting that the density of glassy trehalose(1.49 (4)or1.54gcm −3 (28))is higher (lower free volume) than that of glassy sucrose (1.43 g cm −3 )...
    • ...(4,28). Since there is no broad agreement of the density values, caution must be exercised in general comparison of literature density values...

    Ion Drancaet al. Implications of Global and Local Mobility in Amorphous Sucrose and Tre...

    • ...[ 1 ] and Taylor and Zografi[ 2 ] conducted FT-RAMAN analyses of freeze-dried disaccharides and oligosaccharides containing polyvinylpyrrolidone (PVP) as the polymer additive and, based on the negative shift in the absorption band due to the C=O stretching vibration of PVP, concluded that sugar–PVP hydrogen bond had formed...

    Koreyoshi Imamuraet al. Fourier Self-Deconvolution Analysis of Hydrogen Bonding States of Poly...

    • ...The lack of anti-plasticization of a low molecular weight material by small concentrations of a polymer has been observed previously (17,37)...
    • ...The stabilizing ability of a polymer has been described in the literature in terms of its ability to decrease free volume (37), decrease molecular mobility (24,45), increase the glass transition temperature (46), disrupt drugYdrug interactions (11), and form drugYpolymer interactions (10Y12)...

    Patrick J. Marsacet al. A Comparison of the Physical Stability of Amorphous Felodipine and Nif...

    • ...Thus, assuming the chemical reactivity is linked to the structural relaxation rate, it is expected that sucrose would increase the rate of chemical degradation of CEF while trehalose would have little effect on the rate of degradation (30)...
    • ...It has been shown that in general some degree of interaction between two components is necessary for miscibility to occur (30,31)...
    • ...Even in miscible systems interactions present between like molecules (i.e., aa, bb) will prevent complete coupling of molecular motions between two unlike components (i.e., ab) (30,31)...

    Sheri L. Shamblinet al. Coupling Between Chemical Reactivity and Structural Relaxation in Phar...

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