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Mutations affecting development of the zebrafish inner ear and lateral line

Mutations affecting development of the zebrafish inner ear and lateral line,T. T. Whitfield,M. Granato,F. J. Van Eeden,U. Schach,M. Brand,M. Furutani-

Mutations affecting development of the zebrafish inner ear and lateral line   (Citations: 94)
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T. T. Whitfield, M. Granato, F. J. Van Eeden, U. Schach, M. Brand, M. Furutani-seiki, P. Haffter, M. Hammerschmidt, C. P. Heisenberg, Y. J. Jiang, D. A. Kane, R. N. Kelshhttp://academic.research.microsoft.com/io.ashx?type=5&id=3431813&selfId1=0&selfId2=0&maxNumber=12&query=
Published in 1996.
Cumulative Annual
    • ...First, BPA pulse treatments of different lengths were started at 10 hpf and continued until 18, 24, 30 or 38 hpf, a time frame covering the main steps of otic vesicle development that are shown on Figure 2A [47]...
    • ...Whitfield et al. [47] carried out a large scale screen of zebrafish mutants induced by N-ethyl-N-nitrosurea treatment...
    • ...Mutations occurring in no less than 58 genes leading to defects in the development of either the semicircular canals and/or the otoliths were identified [47]...
    • ...Most of the phenotypes of otolith formation are caused by the specific knock-down or mutation of a given gene [47,68]...

    Yann Gibertet al. Bisphenol A induces otolith malformations during vertebrate embryogene...

    • ...The inner ear was found to be affected in the mutants that exhibit the circling behavior (Nicolson et al.,1998; Whitfield et al.,1996)...

    Mirjam Froehlicheret al. Estrogen receptor subtype β2 is involved in neuromast development in z...

    • ...Mutagenesis screens in zebrafish have uncovered several types of mutants with semicircular canal defects [8-10]...
    • ...Mutagenesis screens in zebrafish combined with positional cloning approaches have traditionally been used to identify genes that contribute to ear development [8-10]...
    • ...For example, the zebrafish dog-eared mutation was identified in a largescale ENU screen by abnormal morphology of the inner ear [10]...

    Jessica A Petkoet al. Proteomic and functional analysis of NCS1 binding proteins reveals nov...

    • ...(74). One hundred and twenty hours post fertilization live zebrafish embryos were immersed in 1 mM DASPEI in embryo medium for 5 min (supernatant only)...

    Tanya L. Henshallet al. Selective neuronal requirement for huntingtin in the developing zebraf...

    • ...It has been suggested that the directionality of this collective cell migration is not controlled by a gradient of an extrinsic guidance molecule, but rather by the polarized expression of the two chemokine receptors, cxcr7b and cxcr4b, within the primordium (Dambly-Chaudiere et al., 2007; Haas and Gilmour, 2006; Valentin et al., 2007)...
    • ...Coordinated directional migration requires asymmetric expression of the chemokine receptors, cxcr4b and cxcr7b, in the primordium and expression of the ligandsdf1a (cxcl12a) in a narrow stripe along the horizontal myoseptum (Dambly-Chaudiere et al., 2007; David et al., 2002; Haas and Gilmour, 2006; Li et al., 2004; Valentin et al., 2007)...
    • ...In WT primordia, cxcr4b is most highly expressed in the leading zone of the primordium and is downregulated in trailing cells (Figure 6A) (Valentin et al., 2007)...
    • ...Conversely, cxcr7b is excluded from the leading zone but is strongly expressed in the trailing half of the primordium and in deposited cells (Figure 6B) (Dambly-Chaudiere et al., 2007; Valentin et al., 2007)...
    • ...Support for this conclusion also stems from time-lapse analyses of cxcr7b morpholino-injected embryos in which trailing cells tumble, but tip cells still extend normally toward the tail (Valentin et al., 2007)...

    Andy Amanet al. Wnt/β-Catenin and Fgf Signaling Control Collective Cell Migration by R...

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