Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors
T. Castano, Huanchen Wang, Sara Ballester, C Gonzalez-Garcia, J Hernandez, C Perez, Jimena Cuenca, A Perez-Castillo, Oscar Huertas, José Luis Gelpí, F. Javier Luque, Hengming Kehttp://academic.research.microsoft.com/io.ashx?type=5&id=34327028&selfId1=0&selfId2=0&maxNumber=12&query=
PDE7 inhibitors regulate pro-inflammatory and immune T-cell functions, and are a potentially novel class of drugs particularly useful for treatment of a wide variety of immune and inflammatory disorders. Structural optimization of thioxoquinazoline derivatives led to new compounds with very interesting profiles as PDE7 or PDE7/PDE4 dual inhibitors, which may be further developed as new drugs for inflammatory and neurological diseases.
, vol. 4, no. 5, pp. 866-876, 2009