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Independent clinical validation of a Canadian FRAX® tool: Fracture prediction and model calibration

Independent clinical validation of a Canadian FRAX® tool: Fracture prediction and model calibration,10.1002/jbmr.123,Journal of Bone and Mineral Resea

Independent clinical validation of a Canadian FRAX® tool: Fracture prediction and model calibration   (Citations: 14)
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    • ...More recently, the Canadian FRAX tool was validated in Manitoba, a Canadian province that did not participate in CaMos or the initial development of FRAX [23]...

    L.-A. Fraseret al. Fracture prediction and calibration of a Canadian FRAX® tool: a popula...

    • ...To adjust for the effect of missing parental hip fracture information on FRAX estimates prior to 2005, age- and sex-specific estimates of the effect of a positive response was determined using the later years of data (2005–2007) as previously described [39]...

    W. D. Leslieet al. Construction of a FRAX ® model for the assessment of fracture probabil...

    • ...Since its publication this tool has also been used to know the risk of fracture in other population cohorts in Europe, the United States of America, Canada, and Japan [25-30]...
    • ...Likewise, since its publication this tool has undergone new adjustments and calibrations for different populations [30]...

    Rafael Azagraet al. Prediction of absolute risk of fragility fracture at 10 years in a Spa...

    • ...Recent work has validated calibration and discrimination of the Canadian FRAX tool using 10-year CaMos data and the Manitoba Bone Density Program [35, 36]...
    • ...Our study does not indicate that the additional clinical risk factors used in FRAX are unimportant, as the derivation meta-analyses and a recent report work in the Manitoba cohort show independent contributions to fracture risk prediction in individuals with those risk factors [15, 16, 36]...

    W. D. Leslieet al. Construction and validation of a simplified fracture risk assessment t...

    • ...Prior fracture and other conditions required for calculating fracture probability with FRAX were assessed through a combination of hospital discharge abstracts (diagnoses and procedures coded using the ICD-9-CM prior to 2004 and ICD-10-CA thereafter) and physician billing claims (coded using ICD-9-CM) as previously described [24]...
    • ...We adjusted for the effect of incomplete parental hip fracture information on FRAX probability estimates prior to 2005 using age- and sexspecific adjustment factors derived from 2005 to 2008 parental hip fracture responses as previously described [24]...
    • ...FRAX predictions with the Canadian FRAX tool have been shown to agree closely with observed fracture rates in our cohort and in the general Canadian population [24, 25]...
    • ...Based upon ROC analyses, fracture probability with BMD provided the highest degree of fracture discrimination with higher AUCs than fracture probability without BMD or BMD alone, as has been noted previously [16, 24]...

    W. D. Leslieet al. Fracture risk assessment without bone density measurement in routine c...

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